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首页> 外文期刊>Medical oncology >Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC).
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Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC).

机译：肝细胞癌（HCC）中Cox-2，Survivin和Bcl-2表达的临床意义。

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Cox-2, Survivin and Bcl-2 are frequently overexpressed in numerous types of cancers. They are known to be the important regulators of apoptosis. This study was designed to investigate the correlation between the clinical characteristics and the expression of Cox-2, Survivin and Bcl-2 in hepatocellular carcinoma. A total of 63 postoperative hepatocellular carcinoma (HCC) samples, 10 adjacent non-tumor samples and 10 normal liver samples were immunochemically detected for the expression of Cox-2, Survivin and Bcl-2. A median follow-up of 4 years for the 63 HCC patients was conducted. Univariate tests and multivariate Cox regression were performed for statistical analysis. The Kaplan-Meier method was used to analyze the survival. Positive expression of Cox-2 (84.3%) and Survivin (77.8%) was detected significantly more frequently in the HCC samples than in the normal liver tissues (30% and 0, respectively). Bcl-2 was highly expressed in the adjacent non-tumor tissue. Cox-2 was positively correlative to Survivin. Survivin and Bcl-2 were significantly associated with the pathological grade of HCC (P<0.05). Expression of both Cox-2 and Survivin was significantly associated with the poor overall survival (OS) (P=0.0141, P=0.0039). Furthermore, multivariate analysis confirmed the independent prognostic value of Survivin expression, along with tumor size and hepatic function. Cox-2 and Survivin were highly expressed in the HCC tissue. Survivin and Bcl-2 were significantly associated with the pathological grade of HCC. The expression of Survivin was an independent prognostic factor for HCC after a hepatectomy. Treatment that inhibits Survivin may be a promising targeted approach in HCC.
机译：Cox-2，Survivin和Bcl-2在多种类型的癌症中经常过表达。已知它们是凋亡的重要调节剂。本研究旨在探讨肝细胞癌临床特征与Cox-2，Survivin和Bcl-2表达之间的相关性。免疫化学检测了总共63个术后肝细胞癌（HCC）样本，10个相邻非肿瘤样本和10个正常肝样本的Cox-2，Survivin和Bcl-2的表达。对63例HCC患者进行了4年的中位随访。进行单因素检验和多因素Cox回归以进行统计分析。使用Kaplan-Meier方法分析生存率。在HCC样本中检测到Cox-2（84.3％）和Survivin（77.8％）阳性表达的频率明显高于正常肝组织（分别为30％和0）。 Bcl-2在相邻的非肿瘤组织中高表达。 Cox-2与Survivin呈正相关。 Survivin和Bcl-2与肝癌的病理分级显着相关（P <0.05）。 Cox-2和Survivin的表达均与不良的总生存期（OS）显着相关（P = 0.0141，P = 0.0039）。此外，多变量分析证实了Survivin表达的独立预后价值，以及肿瘤大小和肝功能。 Cox-2和Survivin在肝癌组织中高表达。 Survivin和Bcl-2与肝癌的病理分级显着相关。 Survivin的表达是肝切除术后HCC的独立预后因素。抑制Survivin的治疗可能是HCC中有希望的靶向方法。

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