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Perceived barriers to research in undergraduate medicine

机译：认识到医学研究的障碍

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In a previous study, heat transfer coefficients of different 10mL tubing and molded vials were determined gravimetrically via sublimation tests with pure water. Contrary to "conventional wisdom", only small differences in Kv values between tubing and molded vials were found in the pressure range relevant for pharmaceutical freeze-drying. In order to investigate the impact of these relatively small differences on the primary drying time of an actual product, freeze-drying experiments with 5% gentamicin sulfate solution as a model system were performed at 68, 100 and 200 mTorr. The primary drying times of the API in recently developed molded (EasyLyo?), tubing (TopLyo?) and polymer vials (TopPac?) were compared. At 68 and 100 mTorr the primary drying time of the drug in the glass vials only differed by 3% to 4%, while the polymer vial took around 9% longer. At 200 mTorr, the API in the EasyLyo? vials dried approximately 15% faster compared to the other vial types. The present study suggest that molded vials that have been modified in design to have better heat transfer properties can achieve drying times comparable to tubing vials.
机译：在先前的研究中，通过使用纯水进行升华测试，通过重量分析法确定了10mL不同管材和模制小瓶的传热系数。与“常规知识”相反，在与药品冷冻干燥相关的压力范围内，仅发现管材和模塑小瓶之间Kv值的微小差异。为了研究这些相对小的差异对实际产品初次干燥时间的影响，以5％硫酸庆大霉素溶液为模型系统进行了68、100和200 mTorr的冷冻干燥实验。比较了最近开发的模制（EasyLyo？），管材（TopLyo？）和聚合物小瓶（TopPac？）中API的主要干燥时间。在68和100 mTorr时，玻璃小瓶中药物的主要干燥时间仅相差3％至4％，而聚合物小瓶所需的干燥时间长约9％。 EasyLyo中的API在200 mTorr时是否可用？与其他类型的样品瓶相比，样品瓶干燥快约15％。本研究表明，经过设计改进以具有更好的传热性能的模制小瓶可以实现与管形小瓶相当的干燥时间。

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