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Polyacrylamide phantom for self-actuating needle-tissue interaction studies

机译：聚丙烯酰胺模型用于自驱动针-组织相互作用的研究

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摘要

This study presents a polyacrylamide gel as a phantom material for needle insertion studies specifically developed for self-actuating needles to enhance the precise placement of needles in prostate. Bending of these self-actuating needles within tissue is achieved by Nitinol actuators attached to the needle body; however these actuators usually involve heating that can thermally damage the tissue surrounding the needles. Therefore, to develop and access feasibility of these needles, a polyacrylamide gel has been developed that mimics the thermal damage and mechanical properties of prostate tissue. Mechanical properties of the polyacrylamide gel was controlled by varying the concentrations of acrylamide monomer and N,. N-methylene-bisacrylamide (BIS) cross-linker, and thermal sensitivity was achieved by adding bovine serum albumin (BSA) protein. Two polyacrylamide gels with different concentrations were developed to mimic the elastic modulus of the tissue. The two phantoms showed different rupture toughness and different deflection of bevel-tip needle. To study the thermal damage, a Nitinol wire was embedded in the phantom and resistively heated. The measured opaque zone (0.40. mm) formed around the wire was close to the estimated damage zone (0.43. mm) determined using the cumulative equivalent minutes at 43 °C.
机译：这项研究提出了一种聚丙烯酰胺凝胶，作为一种用于幻影材料的针头插入研究，专门用于自致动针头，以增强针头在前列腺中的精确放置。这些自致动针头在组织内的弯曲是通过将镍钛诺致动器连接到针头主体上来实现的。然而，这些致动器通常涉及加热，该加热会热损伤针周围的组织。因此，为了开发和使用这些针头的可行性，已开发出一种模仿前列腺组织的热损伤和机械性能的聚丙烯酰胺凝胶。通过改变丙烯酰胺单体和N 1的浓度来控制聚丙烯酰胺凝胶的机械性能。 N-亚甲基双丙烯酰胺（BIS）交联剂，并通过添加牛血清白蛋白（BSA）蛋白获得热敏感性。开发了两种不同浓度的聚丙烯酰胺凝胶，以模仿组织的弹性模量。这两个模型显示出不同的断裂韧性和斜角针的不同挠度。为了研究热损伤，将镍钛诺线嵌入模型中并进行电阻加热。导线周围形成的测得的不透明区域（0.40。mm）接近使用在43°C下累积的等效分钟数确定的估计损坏区域（0.43。mm）。

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