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首页> 外文期刊>Medicinal chemistry >Germatranyl substituted organotin (IV) carboxylates: synthesis spectroscopic characterization and biological activities.
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Germatranyl substituted organotin (IV) carboxylates: synthesis spectroscopic characterization and biological activities.

机译：Germatranyl取代的有机锡（IV）羧酸盐：合成光谱表征和生物活性。

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摘要

Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO](4-n)SnR(2)n, where n= 2, R(2) = C2H5 (1-5); R(1) = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R(2) = CH2C6H5 (6-8), R(1) = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mossbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.
机译：八个新的通式[N（CH2CH2O）3GeCH（R1）CH2COO]（4-n）SnR（2）n的有机锡（IV）衍生物，其中n = 2，R（2）= C2H5（1-5）; R（1）= CH3（1）; C6H5（2）;对CH3C6H4（3）; p-FC6H4（4）; p-CH3OC6H4（5）和n = 3，R（2）= CH2C6H5（6-8），R（1）= CH3（6）; C6H5（7）; p-CH3C6H4（8）是通过使二有机锡或三有机锡氯化物与相应的庚二烷基（取代的）丙酸以适当的摩尔比，以三乙胺为碱反应合成的。合成的化合物通过各种光谱技术进行表征，例如红外光谱，多核（1H，13C，119Sn）NMR，119mSn Mossbauer以及元素分析。还对它们进行了体外抗利什曼原虫前鞭毛体的抗利什曼活性的筛选，并发现了一些令人鼓舞的结果。

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