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首页> 外文期刊>Medicinal Plants >Anti-Mycobaterial potential of Dolichandrone falcata (Wall, ex DC.) Seem. (Bignoniaceae)
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Anti-Mycobaterial potential of Dolichandrone falcata (Wall, ex DC.) Seem. (Bignoniaceae)

机译：Dolichandrone falcata（Wall，ex DC。）的抗霉菌潜力。 （紫花菊科）

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In the present study antibacterial activity of aqueous and alcoholic extracts of stem bark and leaves of Dolichandrone falcata (Wall, ex DC.) Seem (Bignoniaceae) was tested against MDR isolates DKU-156 and JAL-1236 of M. tuberculosis, reference susceptible strain M. tuberculosis H37Rv as well as fast growing mycobacterial pathogen M. fortuitum (TMC-1529). The leaves and bark collected between spring and summer season were dried and extracts was prepared using three portions of the dried powdered barkand leaves. It was soaked separately in 500 ml of distilled water and ethanol (98%) for 72 h and refluxed and filtrates were concentrated under vacuum at 40° C to obtain the dry extracts. Reference drug susceptible strain M. tuberculosis H37Rv as control, multi-drug resistant isolates DKU-156, JAL-1236 and fast growing mycobacterial pathogen M. fortuitum (TMC-1529) were used during the present investigation. Antimicrobial assays were performed in Lowenstein Jensen (L-J) medium and Middlebrook 7H9 broth in BacT/ALERT 30 system (Sigma-Aldrich, St. Louis, USA). The aqueous and alcoholic extracts of stem bark and leaves were incorporated in the media. Susceptibility testing of MDR isolates was also performed against streptomycin in the same batch of media for comparison of cfu on drug free controls. The results of the present investigation clearly showed that the aqueous extracts of stem bark were more effective as compared to aqueous and leaf extracts and alcoholic stem bark and leaf extracts.
机译：在本研究中，Dolichandrone falcata（Wall，ex DC。）的茎皮和叶片的水和酒精提取物的抗菌活性针对参照敏感菌株的结核分枝杆菌的MDR分离物DKU-156和JAL-1236进行了测试（Bignoniaceae）。结核分枝杆菌H37Rv以及快速生长的分枝杆菌病原体Fortuitum（TMC-1529）。将春季和夏季之间收集的叶子和树皮干燥，并使用三份干燥的粉末状树皮叶子制备提取物。将其分别浸入500ml蒸馏水和乙醇（98％）中72小时，然后回流，将滤液在40℃真空浓缩，得到干提取物。在本研究过程中，使用了对参考药物敏感的结核分枝杆菌H37Rv作为对照，对多药耐药的分离株DKU-156，JAL-1236和快速生长的分枝杆菌病原菌M.fortuitum（TMC-1529）。抗菌测定是在Lowenstein Jensen（L-J）培养基和Middlebrook 7H9肉汤中于BacT / ALERT 30系统（Sigma-Aldrich，圣路易斯，美国）中进行的。将茎皮和叶片的水和酒精提取物掺入培养基中。还对同一批培养基中的链霉素进行了MDR分离物的药敏试验，以比较无药物对照中的cfu。本研究的结果清楚地表明，与水提取物和叶提取物以及酒精性茎皮和叶提取物相比，茎皮的水提取物更有效。

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