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首页> 外文期刊>Medicinal Plants >Phytochemical investigations and systematic exploration of anti-cancer potential of leaves of Nyctanthes arbor-tristis
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Phytochemical investigations and systematic exploration of anti-cancer potential of leaves of Nyctanthes arbor-tristis

机译：夜蛾（Nyctanthes arbor-tristis）叶片的植物化学研究和抗癌潜力的系统探索

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Leaves of Nyctanthes arbor-tristis have been traditionally used as anti-cancer drug, but there is no report to support this traditional claim. The present study is undertaken to establish the anti-cancer activity of the N. arbor-tristis, and to identify the most active anticancer fraction(s) from its different extracts. Leaves of N. arbor-tristis were extracted with solvents of varied polarity (toluene, chloroform, ethylacetate and aqueous ethanol (HA), and subsequently evaluated for their anti-cancer activity against HL60 cell lines using MTT assay method. The toluene and HA extracts were fractionated through column chromatography and successive solvent extractions, respectively. All extracts, except ethyl acetate extract, exhibited potent anti-cancer activity. Four fractions of the toluene extract were found maximally potent whereas the petroleum ether fraction of HA was found responsible for anti-cancer activity of HA extract. It is concluded that the plant can serve as an excellent source of potent and probably new anti-cancer lead(s), which can be further modified chemically to produce a series of compounds for development of potent and safe anti-cancer drugs.
机译：传统上已将乔木夜蛾的叶子用作抗癌药，但尚无报道支持这一传统主张。进行本研究以建立乔木猪笼草的抗癌活性，并从其不同提取物中鉴定最具活性的抗癌组分。用不同极性的溶剂（甲苯，氯仿，乙酸乙酯和乙醇水溶液（HA））提取乔木猪笼草的叶子，然后使用MTT分析法评估其对HL60细胞系的抗癌活性。分别通过柱色谱和连续溶剂萃取进行分馏，除乙酸乙酯萃取物外，所有萃取物均显示出有效的抗癌活性，甲苯萃取物中的四个馏分均显示出最大的效力，而HA的石油醚馏分则具有抗癌作用。 HA提取物具有抗癌活性，可以得出结论该植物可以作为有效的强力来源，并且可能是新的抗癌药，可以对其进行化学修饰以生产出一系列化合物，以开发有效而安全的抗癌药。 -癌症药物。

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