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首页> 外文期刊>Medicinal chemistry >Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondyliutn pseudo-candidum
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Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondyliutn pseudo-candidum

机译：Ppc-1的抗菌和抗炎活性，细胞粘液霉Polysphondyliutn假念珠菌的活性成分

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摘要

The diisopentenyloxy quinolobactin derivative 3-methylbut-2-eny1-4-methoxy-8-[(3-methylbut-2-enyl)oxy] quinoline-2-carboxylate, also named as Ppc-1, has been initially isolated from the fruiting bodies of the cellular slime mold Polysphondylium pseudo-candidunz. Given that few data are available in the literature concerning the biological properties of this compound, this study was undertaken to evaluate its antibacterial and anti-inflammatory properties. Ppc-1 exerted antibacterial activity on the Gram negative periodontopathogen Porphyromonas gingivalis, while it had no such effect on the other bacterial species tested. The antibacterial activity of Ppc-1 appeared to result from its ability to permeate the cell membrane. Using the U937-3xxB-LUC human monocytic cell line, Ppc-1 was found to dose-dependently inhibit the lipopolysaccharide-induced NF-KB activation, a signaling pathway that has been associated with inflammatory mediator secretion. In conclusion, Ppc-1, by exhibiting a dual mode of action including antibacterial and anti-inflammatory activities, may represent a promising targeted therapeutic agent for periodontal diseases.
机译：最初从果实中分离出了二异戊烯氧基喹啉烟草衍生物3-甲基丁-2-烯基1-4-甲氧基-8-[（3-甲基丁-2-烯基）氧基]喹啉-2-羧酸酯，也称为Ppc-1。细胞粘液霉菌的假体Polysphondylium pseudo-candidunz。鉴于文献中关于该化合物生物学特性的数据很少，因此进行了这项研究以评估其抗菌和抗炎特性。 Ppc-1对革兰氏阴性牙周病原体牙龈卟啉单胞菌具有抗菌活性，而对其他测试细菌则没有这种作用。 Ppc-1的抗菌活性似乎是由其渗透细胞膜的能力引起的。使用U937-3xxB-LUC人单核细胞系，发现Ppc-1剂量依赖性地抑制脂多糖诱导的NF-KB活化，这是一种与炎症介质分泌有关的信号通路。总之，Ppc-1具有双重作用方式，包括抗菌和消炎作用，可能代表了有希望的针对牙周疾病的靶向治疗剂。

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