Biologically Active New N, N ', N ''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization

Gul Rukhsana; Altaf Ataf A.; Khan Azim; Badshah Amin; Shah Afzal; Rehman Zia Ur; Naz Rabia; Tahir Muhammad N.; Junaid Asif

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Biologically Active New N, N ', N ''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization

机译：具有生物活性的新的N，N'，N''-三取代的二茂铁基苯基胍及其表征

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Background: Introducing new candidates for various biological targets is a prime characteristic of the present day medicinal research and development. Guanidines are the important bioactive compounds and are well recognized for their diverse biological activities, especially as anticancer, antimicrobial and antioxidant agents. Due to the favorable electronic properties of ferrocene like lipophilicity, redox activity, stability in solution state and its easy derivatization, have made ferrocenyl compounds very popular molecules for biological uses. Objectives: Keeping in sight, it is valuable to synthesize ferrocenyl guanidines to increase the binding potency with DNA, make them redox active and more lipophilic compounds.

机译：背景：为各种生物学目标引入新的候选物是当今医学研究和开发的主要特征。胍是重要的生物活性化合物，并因其多种生物活性而广为人知，尤其是作为抗癌剂，抗微生物剂和抗氧化剂。由于二茂铁的良好的电子性质，如亲脂性，氧化还原活性，溶液状态的稳定性及其易于衍生化，使得二茂铁基化合物成为非常流行的生物用途分子。目的：密切注意，合成二茂铁胍胍以增加与DNA的结合力，使其具有氧化还原活性和更多亲脂性化合物是很有价值的。

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来源
《Medicinal chemistry》 |2016年第7期|共15页
作者
Gul Rukhsana; Altaf Ataf A.; Khan Azim; Badshah Amin; Shah Afzal; Rehman Zia Ur; Naz Rabia; Tahir Muhammad N.; Junaid Asif;
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正文语种 eng
中图分类医用化学;
关键词
Synthesis; crystal structure; DNA binding; antioxidant activity; antifungal activity; antibacterial activity;

机译：合成;晶体结构;DNA结合;抗氧化活性;抗真菌活性;抗菌活性;

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1. Biologically Active New N, N ', N ''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization [J] . Gul Rukhsana, Altaf Ataf A., Khan Azim, Medicinal chemistry . 2016,第7期

机译：具有生物活性的新的N，N'，N''-三取代的二茂铁基苯基胍及其表征
2. Microwave-assisted Synthesis, Characterization, and Density Functional Theory Study of Biologically Active Ferrocenyl Bis-pyrazoline and Bis-pyrimidine as Organometallic Macromolecules [J] . Khan Salman A., Asiri Abdullah M., Zayed Mohie E. M., Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2019,第1期

机译：微波辅助合成，表征和密度函数理论研究生物活性二茂铁BIS-吡唑啉和双嘧啶作为有机金属大分子
3. Biologically active halo-substituted ferrocenyl thioureas: synthesis, spectroscopic characterization, and DFT calculations [J] . Asghar Faiza, Rana Sadaf, Fatima Saira, New Journal of Chemistry . 2018,第9期

机译：生物活性卤素取代的铁核基硫脲：合成，光谱表征和DFT计算
4. Title: Characterization of Microbial Community Structures and the Occurrence of Antibiotic Resistance Genes for the Optimization of Biologically Active Filtration for Potable Reuse Applications [C] . Matthew Blair, Amy Pruden, Charles Bott Annual Water Environment Federation technical exhibition and conference . 2019

机译：发言题目：微生物群落结构的表征和抗生素抗性基因的出现，可优化可重复使用的生物活性滤池
5. Tissue Engineering Active Biological Machines: Bio-Inspired Design, Directed Self-Assembly, and Characterization of Muscular Pumps Simulating the Embryonic Heart. [D] . Azizgolshani, Hesham. 2013

机译：组织工程学主动生物机器：生物启发设计，定向自组装和模拟胚胎心脏的肌肉泵的特性。
6. Microwave Assisted Synthesis Characterization and Biological Activities of Ferrocenyl Chalcones and Their QSAR Analysis [O] . Dinesh K. Yadav, Parshant Kaushik, Pankaj, 2019

机译：微波辅助合成特征和生物活性的铁茂氨基核糖碱及其QSAR分析
7. Synthesis and characterization of symmetrical and unsymmetrical ferrocenyl ligands for use in the preparation of Redox Active Ruthenium Alkylidene Complexes [O] . Saku Duduetsang 2007

机译：用于制备氧化还原活性亚钌亚烷基配合物的对称和不对称二茂铁配体的合成和表征
8. Characterization of the corrosion resistance of biologically active solutions: The effects of anodizing and welding [R] . Walsh, Daniel W. 1991

机译：表征生物活性溶液的耐腐蚀性：阳极氧化和焊接的影响

Biologically Active New N, N ', N ''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization

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