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首页> 外文期刊>Medicinal chemistry >Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator
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Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator

机译：血浆Omega-3脂肪酸与花生四烯酸之间的竞争性相互作用与信号传递介质的下调有关

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摘要

Autism spectrum disorders (ASD) may be attributed to altered composition of polyunsaturated fatty acids. We examined the relationships between the plasma ratios of docosahexaenoic acid (DHA)/arachidonic acid (AA) and eicosapentaenoic acid (EPA)/AA, and biomarkers of AA-related signaling mediators, i.e., ceruloplasmin, transferrin and superoxide dismutase, with the behavioral symptoms of 30 individuals with ASD (mean age, 13.0 years old) and 20 age-and gender-matched normal controls (mean age, 13.6 years old). Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). The ASD group had significantly higher plasma DHA/AA and EPA/AA ratios, as well as ABC scores, compared to the control group. The plasma ceruloplasmin levels in the ASD group were significantly reduced compared to those in the control group. Multiple linear regression demonstrated that plasma DHA/AA ratio was a fitting model for distinguishing the ASD group from the control group. These findings suggested that increased plasma DHA/AA ratio may be related to lower plasma levels of ceruloplasmin, which may contribute to the pathophysiology of behavioral symptoms in 30 individuals with ASD.
机译：自闭症谱系障碍（ASD）可能归因于多不饱和脂肪酸组成的改变。我们检查了二十二碳六烯酸（DHA）/花生四烯酸（AA）和二十碳五烯酸（EPA）/ AA的血浆比率与AA相关信号传递介质的生物标志物，即铜蓝蛋白，转铁蛋白和超氧化物歧化酶之间的关系。 30名ASD患者（平均年龄13.0岁）和20名年龄和性别相匹配的正常对照（平均年龄13.6岁）的症状。使用异常行为清单（ABC）评估行为症状。与对照组相比，ASD组的血浆DHA / AA和EPA / AA比率以及ABC评分明显更高。与对照组相比，ASD组的血浆铜蓝蛋白水平显着降低。多元线性回归表明，血浆DHA / AA比是区分ASD组和对照组的合适模型。这些发现表明，血浆DHA / AA比例升高可能与血浆铜蓝蛋白水平降低有关，这可能与30名ASD患者行为症状的病理生理有关。

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