Therapeutic potential of fucosyltransferases in cancer and recent development of targeted inhibitors

Lv Y.; Zhang Z.; Tian S.Wang W.Li H.

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Therapeutic potential of fucosyltransferases in cancer and recent development of targeted inhibitors

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? 2022 Elsevier LtdFucosyltransferases (FUTs) have significant roles in various pathophysiological events. Their high expression is a signature of malignant cell transformation, contributing to many abnormal events during cancer development, such as uncontrolled cell proliferation, tumor cell invasion, angiogenesis, metastasis, immune evasion, and therapy resistance. Therefore, FUTs have evolved as an attractive therapeutic target for treating solid cancers, and many substrate analogs have been discovered with potential as FUT inhibitors for cancer therapy. Meanwhile, the development of FUT protein structures represents a significant advance in the design of FUT inhibitors with nonsubstrate structures. In this review, we summarize the role of FUTs in cancers, the resolved protein crystal structures and progress in the development of FUT inhibitors as cancer therapeutics.

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《Drug discovery today》 |2023年第1期|103394-103394|共6页
作者
Lv Y.; Zhang Z.; Tian S.Wang W.Li H.;
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作者单位

College of Pharmaceutical Sciences Soochow University;

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原文格式 PDF
正文语种英语
中图分类药学;
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Cancer therapy; Crystal structures; Fucosyltransferases; Glycosylation; Inhibitors;

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Therapeutic potential of fucosyltransferases in cancer and recent development of targeted inhibitors

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