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首页> 外文期刊>Mathematical Biosciences: An International Journal >Effects of education, vaccination and treatment on HIV transmission in homosexuals with genetic heterogeneity
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Effects of education, vaccination and treatment on HIV transmission in homosexuals with genetic heterogeneity

机译：教育，疫苗接种和治疗对具有遗传异质性的同性恋者传播艾滋病毒的影响

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Genetic studies report the existence of a mutant allele Delta32 of CCR5 chemokine receptor gene at high allele frequencies (similar to10%) in Caucasian populations. The presence of this allele is believed to provide partial or full resistance to HIV. In this study, we look at the impact of education, temporarily effective vaccines and therapies on the dynamics of HIV in homosexually active populations. In our model, it is assumed that some individuals possess one or two mutant alleles (like Delta32 of CCR5) that prevent the successful invasion or replication of HIV. Our model therefore differentiates by genetic and epidemiological status and naturally ignores the reproduction process. Furthermore, HIV infected individuals are classified as rapid, normal or slow progressors. In this complex setting, the basic reproductive number R-0 is derived in various situations. The separate or combined effects of therapies, education, vaccines, and genetic resistance are analyzed. Our results support the conclusions of Hsu Schmitz that some integrated intervention strategies are far superior to those based on a single approach. However, treatment programs may have effects which counteract each other, as may genetic resistance. (C) 2004 Elsevier Inc. All rights reserved. [References: 29]
机译：遗传学研究报告了高等位基因频率（约占10％）的CCR5趋化因子受体基因的突变等位基因Delta32的存在。据认为，该等位基因的存在对HIV提供了部分或全部抗性。在这项研究中，我们研究了教育，临时有效的疫苗和疗法对同性恋活跃人群中HIV动态的影响。在我们的模型中，假设某些人拥有一个或两个突变等位基因（如CCR5的Delta32），它们阻止了HIV的成功入侵或复制。因此，我们的模型通过遗传和流行病学状态来区分，自然忽略了繁殖过程。此外，艾滋病毒感染者被分为快速，正常或缓慢进展者。在这种复杂的情况下，基本生殖数R-0在各种情况下都可以得出。分析了治疗，教育，疫苗和遗传抗性的单独或组合作用。我们的结果支持Hsu Schmitz的结论，即某些综合干预策略远优于基于单一方法的策略。但是，治疗程序可能会相互抵消，遗传抗性也可能互相抵消。 （C）2004 Elsevier Inc.保留所有权利。 [参考：29]

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