Multi-objective experimental design for C-13-based metabolic flux analysis

Bouvin Jeroen; Cajot Simon; DHuys Pieter-Jan; Ampofo-Asiama Jerry; Anne Jozef; Van Impe Jan; Geeraerd Annemie; Bernaerts Kristel

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Multi-objective experimental design for C-13-based metabolic flux analysis

机译：基于C-13的代谢通量分析的多目标实验设计

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C-13-based metabolic flux analysis is an excellent technique to resolve fluxes in the central carbon metabolism but costs can be significant when using specialized tracers. This work presents a framework for cost-effective design of C-13-tracer experiments, illustrated on two different networks.

机译：基于C-13的代谢通量分析是一种解决中央碳代谢中通量的出色技术，但使用专门的示踪剂时，成本可能很高。这项工作为两个不同的网络上展示的C-13示踪剂实验的高性价比设计提供了一个框架。

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来源
《Mathematical Biosciences: An International Journal》 |2015年第null期|共9页
作者
Bouvin Jeroen; Cajot Simon; DHuys Pieter-Jan; Ampofo-Asiama Jerry; Anne Jozef; Van Impe Jan; Geeraerd Annemie; Bernaerts Kristel;
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正文语种 eng
中图分类生物数学方法;
关键词
C-13-based metabolic flux analysis; Multi-objective optimal experimental design; Streptomyces lividans; Central carbon metabolism; Carcinoma cell line; Cost-effective experimental design;

机译：基于C-13的代谢通量分析;多目标最优实验设计;青霉链霉菌;中央碳代谢;癌细胞系;性价比高的实验设计;

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专利

1. Multi-objective experimental design for C-13-based metabolic flux analysis [J] . Bouvin Jeroen, Cajot Simon, DHuys Pieter-Jan, Mathematical Biosciences: An International Journal . 2015,第Null期

机译：基于C-13的代谢通量分析的多目标实验设计
2. GC-QTOFMS with a low-energy electron ionization source for advancing isotopologue analysis in C-13-based metabolic flux analysis [J] . Mairinger Teresa, Sanderson Jennifer, Hann Stephan Analytical and bioanalytical chemistry . 2019,第8期

机译：GC-QTOFMS具有低能量电子电离源，用于推进基于C-13的代谢通量分析的同位素分析
3. Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by C-13-based metabolic flux analysis [J] . Tomas-Gamisans Marius, Odum Anders Sebastian Rosenkrans, Workman Mhairi, New biotechnology . 2019,第期

机译：基于C-13的代谢通量分析，甘油代谢的甘油代谢（Komagateella SPP。）
4. Metafluxnet, A Program Package For Metabolic Pathway Construction and Analysis, and Its Use in Large-scale Metabolic Flux Analysis of Escherichia Coli [C] . Sang Yup Lee, dong-yup Lee, soon Ho Hong, International Conference on Genome Informatics . 2003

机译：Metafluxnet，代谢途径建设和分析的程序包，其在大肠杆菌大肠杆菌的大规模代谢通量分析
5. Identification of metabolic constraints in clostridium phytofermentans using experimental evolution and metabolic flux analysis. [D] . Mukherjee, Supratim. 2013

机译：使用实验进化和代谢通量分析鉴定破伤风梭菌中的代谢限制。
6. Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis [O] . Martin Beyß, Victor D. Parra-Peña, Howard Ramirez-Malule, 2021

机译：强制化实验示踪设计13C - 代谢通量分析
7. Multi-objective experimental design for 13C-based metabolic flux analysis [O] . Bouvin Jeroen, Cajot Simon, D’Huys Pieter-Jan, 2015

机译：基于13C的代谢通量分析的多目标实验设计
8. Combining Flux Balance and Energy Balance Analysis for Large-Scale Metabolic Network: Biochemical Circuit Theory for Analysis of Large-Scale Metabolic Networks [R] . Beard, Daniel A., Liang, Shou-Dan, Qian, Hong 2001

机译：结合通量平衡和能量平衡分析的大规模代谢网络：生化电路理论分析大规模代谢网络

Multi-objective experimental design for C-13-based metabolic flux analysis

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