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首页> 外文期刊>Methods: A Companion to Methods in Enzymology >Experimental testicular tissue banking to generate spermatogenesis in the future: A multidisciplinary team approach
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Experimental testicular tissue banking to generate spermatogenesis in the future: A multidisciplinary team approach

机译：实验性睾丸组织库在将来产生精子发生：多学科团队方法

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摘要

Spermatogonial stem cell (SSC) loss due to cancer treatment, developmental disorder or genetic abnormality may cause permanent infertility. Cryopreservation of ejaculated sperm is an effective method of fertility preservation in adult males at risk of infertility. However this is not an option in pre-pubertal boys because spermatogenesis has not yet started, and it is difficult in adolescents who are not sexually mature. Therefore testicular tissue cryopreservation to preserve SSCs for future generation of spermatogenesis, either in vivo or in vitro, could be an option for these groups of patients. Although SSC transplantation has been successful in several species including non-human primates, it is still experimental in humans. There are several remaining concerns which need to be addressed before initiating trials of human SSC autotransplantation. Establishment of a testicular tissue banking system is a fundamental step towards using SSC technology as a fertility preservation method. It is important to understand the consultation, harvesting the testicular tissue, histological evaluation, cryopreservation, and long term storage aspects. We describe here a multidisciplinary approach to establish testicular tissue banking for males at risk of infertility. (C) 2016 Elsevier Inc. All rights reserved.
机译：由于癌症治疗，发育障碍或遗传异常导致的精原干细胞（SSC）丢失可能导致永久性不育。冷冻保存精子是对有不孕风险的成年男性生育能力的有效保存方法。但是，在青春期前的男孩中这不是一个选择，因为精子发生尚未开始，并且在未成年的青少年中很难。因此，对于这些类型的患者，睾丸组织冷冻保存以保存SSCs，以供将来在体内或体外产生精子发生。尽管SSC移植已在包括非人类灵长类动物在内的多个物种中获得成功，但仍在人类中进行实验。在开始进行人类SSC自体移植试验之前，还需要解决几个尚存的问题。建立睾丸组织库系统是使用SSC技术作为生育力保存方法的基本步骤。了解会诊，睾丸组织的采集，组织学评估，冷冻保存和长期保存等方面很重要。我们在这里描述了一种多学科方法来建立男性不育风险睾丸组织库。 （C）2016 Elsevier Inc.保留所有权利。

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