Molecular organization of the postsynaptic specialization.

Sheng M

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Molecular organization of the postsynaptic specialization.

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A specific set of molecules including glutamate receptors is targeted to the postsynaptic specialization of excitatory synapses in the brain, gathering in a structure known as the postsynaptic density (PSD). Synaptic targeting of glutamate receptors depends on interactions between the C-terminal tails of receptor subunits and specific PDZ domain-containing scaffold proteins in the PSD. These scaffold proteins assemble a specialized protein complex around each class of glutamate receptor that functions in signal transduction, cytoskeletal anchoring, and trafficking of the receptors. Among the glutamate receptor subtypes, the N-methyl-d-aspartate receptor is relatively stably integrated in the PSD, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor moves in and out of the postsynaptic membrane in highly dynamic fashion. The distinctive cell biological behaviors of N-methyl-d-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors can be explained by their differential interactions with cytoplasmic proteins.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第13期|7058-7061|共4页
作者
Sheng M;
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作者单位

Department of Neurobiology, and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street (Wel 423), Boston, MA 02114, USA. sheng;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Brain; Excitatory Postsynaptic Potentials; Nerve Tissue Proteins; Receptors; AMPA; 脑; 兴奋性突触后电位; 神经组织蛋白质类; 受体; N-甲基-D-天冬氨酸;

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Molecular organization of the postsynaptic specialization.

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