...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Cell >Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
【24h】

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

机译：转录因子PROX1通过促进从良性表型向高度发育异常表型的转变诱导结肠癌的进展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Drosophila transcription factor Prospero functions as a tumor suppressor, and it has been suggested that the human counterpart of Prospero, PROX1, acts similarly in human cancers. However, we show here that PROX1 promotes dysplasia in colonic adenomas and colorectal cancer progression. PROX1 expression marks the transition from benign colon adenoma to carcinoma in situ, and its loss inhibits growth of human colorectal tumor xenografts and intestinal adenomas in Apc(min/+) mice, while its transgenic overexpression promotes colorectal tumorigenesis. Furthermore, in intestinal tumors PROX1 is a direct and dose-dependent target of the beta-catenin/TCF signaling pathway, responsible for the neoplastic transformation. Our data underscore the complexity of cancer pathogenesis and implicate PROX1 in malignant tumor progression through the regulation of cell polarity and adhesion.
机译：果蝇转录因子Prospero可以起到抑癌作用，并且有人提出Prospero的人类对应物PROX1在人类癌症中的作用类似。但是，我们在这里显示PROX1会促进结肠腺瘤和结肠直肠癌进展中的异型增生。 PROX1的表达标志着从良性结肠腺瘤到原位癌的转变，其损失抑制了Apc（min / +）小鼠中人类结直肠肿瘤异种移植物和肠腺瘤的生长，而其转基因的过表达促进了结直肠肿瘤的发生。此外，在肠道肿瘤中，PROX1是β-catenin/ TCF信号通路的直接且剂量依赖性靶标，负责肿瘤的转化。我们的数据强调了癌症发病机制的复杂性，并通过调节细胞极性和粘附力将PROX1参与了恶性肿瘤的进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号