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首页> 外文期刊>Cancer causes and control: CCC >Hepatocellular carcinoma and vinyl chloride.
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Hepatocellular carcinoma and vinyl chloride.

机译：肝细胞癌和氯乙烯。

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摘要

In reviewing the epidemiological and experimental studies on the association between inhalation exposure to vinyl chloride (VC) and hepatocellular carcinoma (HCC), Dra-gani and Zocchetti [1] quoted our article on this topic [2] and wrote that subjects exposed at <2,500 ppm years of VC exposure showed no significant increased risk of HCC. This statement is misleading. In fact, by holding the confounding factors constant at logistic regression analysis, each extra increase of 1,000 ppm years of VCM cumulative exposure was found to increase the risk of HCC by 71% (OR = 1.71; CI = 1.28-2.44) and the risk of liver cirrhosis (LC) by 37% (OR = 1.37; CI = 1.13-1.69). VC exposure appears therefore to be an independent risk factor for HCC and LC. We also found that a high cumulative VC exposure (>2,500 ppm years) interacted synergistically with high alcohol consumption and additively with viral hepatitis infection.
机译：在回顾关于吸入氯乙烯（VC）和肝细胞癌（HCC）之间的关联的流行病学和实验研究时，Dra-gani和Zocchetti [1]引用了我们关于该主题的文章[2]，并写道在< 2,500 ppm年的VC暴露没有显着增加HCC风险。这一说法具有误导性。实际上，通过在Logistic回归分析中将混杂因素保持恒定，发现每增加1000 ppm年的VCM累积暴露量，会使HCC的风险增加71％（OR = 1.71; CI = 1.28-2.44）和肝硬化（LC）的发生率降低了37％（OR = 1.37; CI = 1.13-1.69）。因此，VC暴露似乎是HCC和LC的独立风险因素。我们还发现，高的累积VC暴露量（> 2,500 ppm年）与高饮酒量和病毒性肝炎感染具有协同作用。

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