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Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study.

机译：维生素和矿物质的使用与前列腺癌的风险：病例对照研究。

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BACKGROUND: Many studies have evaluated the association between vitamin and mineral supplement use and the risk of prostate cancer, with inconclusive results. METHODS: The authors examined the relation of use of multivitamins as well as several single vitamin and mineral supplements to the risk of prostate cancer risk among 1,706 prostate cancer cases and 2,404 matched controls using data from the hospital-based case-control surveillance study conducted in the United States. Odds ratios (OR) and 95% confidence intervals (CI) for risk of prostate cancer were estimated using conditional logistic regression model. RESULTS: For use of multivitamins that did not contain zinc, the multivariable odds ratios of prostate cancer were 0.6 for 1-4 years, 0.8 for 5-9 years, and 1.2 for 10 years or more, respectively (p for trend = 0.70). Men who used zinc for ten years or more, either in a multivitamin or as a supplement, had an approximately two-fold (OR = 1.9, 95% CI: 1.0, 3.6) increased risk of prostate cancer. Vitamin E, beta-carotene, folate, and selenium use were not significantly associated with increased risk of prostate cancer. CONCLUSION: The finding that long-term zinc intake from multivitamins or single supplements was associated with a doubling in risk of prostate cancer adds to the growing evidence for an unfavorable effect of zinc on prostate cancer carcinogenesis.
机译：背景：许多研究评估了维生素和矿物质补充剂的使用与前列腺癌风险之间的关联，但结论尚无定论。方法：作者使用来自医院的病例对照监测研究中的数据，检查了1,706例前列腺癌病例和2,404例匹配对照中使用多种维生素以及几种单一的维生素和矿物质补充剂与前列腺癌风险之间的关系。美国。使用条件逻辑回归模型估算患前列腺癌的几率（OR）和95％置信区间（CI）。结果：对于不含锌的多种维生素的使用，前列腺癌的多变量优势比分别为1-4年0.6、0.8 5-9年和1.2 1.2 10年或更长时间（趋势p = 0.70）。 。在多种维生素中或作为补充剂使用锌十年或以上的男性，患前列腺癌的风险增加了大约两倍（OR = 1.9，95％CI：1.0，3.6）。维生素E，β-胡萝卜素，叶酸和硒的使用与前列腺癌风险的增加没有显着相关。结论：从多种维生素或单一补充剂中长期摄入锌与患前列腺癌的风险增加一倍有关的发现，增加了锌对前列腺癌致癌作用不利的证据。

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