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首页> 外文期刊>Cancer causes and control: CCC >Previous pulmonary disease and family cancer history increase the risk of lung cancer among Hong Kong women.
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Previous pulmonary disease and family cancer history increase the risk of lung cancer among Hong Kong women.

机译：先前的肺部疾病和家族癌症史增加了香港女性患肺癌的风险。

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摘要

Chinese women in Hong Kong have among the highest incidence and mortality of lung cancer in the world, in spite of a low prevalence of smoking. We carried out this population-based case-control study to evaluate the associations of previous lung disease and family cancer history with the occurrence of lung cancer among them. We selected 212 cases that were newly diagnosed with primary lung cancer, and randomly sampled 292 controls from the community, frequency matched by age group. All the cases and controls were lifetime nonsmokers. We estimated the main effects of preexisting asthma, pulmonary tuberculosis, pneumonia, chronic bronchitis, and family lung/all cancer history, using unconditional logistic regression, accounting for various potential risk factors and confounders. All of the previous lung diseases, except chronic bronchitis, were related to an elevated risk for lung cancer, and the association with asthma was significant. Those who had more than one previous lung disease tended to be at higher risk than those with only one of them. Positive family history of any cancer was associated with over 2-fold risk than negative family history. The joint effect of positive history of previous pulmonary diseases and positive family cancer history appeared to be additive, indicating the two factors acted independently. The results support an etiological link of preexisting lung disease and family cancer history to the risk of lung cancer.
机译：尽管吸烟率低，香港的中国女性仍然是世界上肺癌发病率和死亡率最高的国家之一。我们进行了这项基于人群的病例对照研究，以评估先前的肺部疾病和家族癌症史与其中肺癌发生之间的关联。我们选择了212例新诊断为原发性肺癌的病例，并从社区中随机抽取292例对照，频率与年龄组相匹配。所有病例和对照均为终生不吸烟者。我们使用无条件逻辑回归分析了先前存在的哮喘，肺结核，肺炎，慢性支气管炎和家庭肺癌/所有癌症病史的主要影响，并考虑了各种潜在的危险因素和混杂因素。除慢性支气管炎外，所有先前的肺部疾病均与肺癌风险升高有关，并且与哮喘的关联也很显着。那些患有一种以上肺部疾病的人比那些只有一种肺部疾病的人有更高的风险。与阴性家族史相比，任何癌症的阳性家族史与超过2倍的风险相关。先前肺部疾病的阳性病史和阳性家族癌病史的联合作用似乎是相加的，表明这两个因素是独立起作用的。结果支持了先前存在的肺病和家族癌症史与肺癌风险的病因学联系。

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