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Age at incident treatment of hypertension and risk of cancer: A population study

机译：高血压的突发事件治疗年龄和罹患癌症的风险：一项人群研究

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Objective: To determine the effect of treated hypertension on the risk of cancer. Methods: Population based external comparison study using the Saskatchewan Health databases. Results: A total of 42,270 subjects were followed for a median of 17.9 years after initiating antihypertensives for hypertension. The effect of hypertension on the risk of cancer varied significantly by age (interaction p < 0.001). Compared with the general population, subjects under 60 years at the time of initiation of antihypertensives had a significantly increased risk of cancer (RR 1.34, 95% CI 1.18-1.52 adjusted for age, sex, and calendar year) while subjects over 60 had a significantly decreased risk (RR 0.88, 95% CI 0.78-0.98). Similar results were obtained for cancer death outcomes. In each subgroup, relative risks across most cancer sites were similar in magnitude and direction. Results were essentially unchanged when analyses were restricted to cancers diagnosed after the first 10 years of follow-up. Conclusions: The effect of treated hypertension on cancer risk varies by the age at incident treatment of hypertension. These findings are not a result of reverse causality or detection bias. However, they may in part be a consequence of residual confounding and/or reflect the type of hypertension being treated.
机译：目的：确定高血压治疗对癌症风险的影响。方法：使用萨斯喀彻温卫生数据库进行基于人群的外部比较研究。结果：在开始对高血压患者使用降压药后，总共对42,270名受试者进行了平均17.9年的随访。高血压对癌症风险的影响因年龄而异（相互作用p <0.001）。与一般人群相比，在开始使用降压药时60岁以下的受试者罹患癌症的风险显着增加（RR 1.34，95％CI 1.18-1.52（根据年龄，性别和日历年进行了调整）），而60岁以上的受试者则具有风险显着降低（RR 0.88，95％CI 0.78-0.98）。对于癌症死亡结果也获得了相似的结果。在每个亚组中，大多数癌症部位的相对风险在大小和方向上都相似。当分析仅限于随访的头10年后诊断出的癌症时，结果基本上没有变化。结论：高血压的治疗对癌症风险的影响因高血压的发病年龄而异。这些发现不是反向因果关系或检测偏见的结果。但是，它们可能部分是残留混杂的结果和/或反映出所治疗的高血压类型。

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