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首页> 外文期刊>Cancer causes and control: CCC >C-reactive protein and ovarian cancer: a prospective study nested in three cohorts (Sweden, USA, Italy).
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C-reactive protein and ovarian cancer: a prospective study nested in three cohorts (Sweden, USA, Italy).

机译：C反应蛋白与卵巢癌：一项前瞻性研究，涉及三个队列（瑞典，美国，意大利）。

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OBJECTIVES: Inflammatory processes may influence the risk of epithelial ovarian cancer, but available epidemiological evidence is limited and indirect. Circulating C-reactive protein (CRP), a sensitive marker of inflammation, may serve as a direct biological marker of an underlying association. METHODS: The association between ovarian cancer risk and pre-diagnostic circulating CRP was tested in a case-control study nested within three prospective cohorts from Sweden, USA, and Italy. The study included 237 cases and 427 individually matched controls. CRP was measured in stored blood samples by high-sensitivity immunoturbidimetric assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by conditional logistic regression. RESULTS: Overall, CRP was not related to risk of ovarian cancer. However, a marked increase in risk was observed for CRP concentrations >10 mg/l: OR (95% CI) 4.4 (1.8-10.9), which remained significant after limiting analyses to cases diagnosed more than two or five years after blood donation (OR 3.0 (1.2-8.0) and 3.6 (1.0-13.2), respectively). Risk of mucinous tumors increased with high CRP, but the number of cases in this analysis was small. CONCLUSION: Study results offer additional support to the concept that chronic inflammation plays a role in epithelial ovarian cancer.
机译：目的：炎症过程可能会影响上皮性卵巢癌的风险，但现有的流行病学证据有限且是间接的。循环C反应蛋白（CRP）是炎症的敏感标志物，可作为潜在关联的直接生物学标志物。方法：在一项病例对照研究中检测了卵巢癌风险与诊断前循环CRP之间的关系，该研究嵌套在瑞典，美国和意大利的三个前瞻性队列中。该研究包括237例病例和427个单独匹配的对照。通过高灵敏度免疫比浊法测定了血液样本中的CRP。通过条件逻辑回归计算赔率（OR）和95％置信区间（CI）。结果：总体而言，CRP与卵巢癌的风险无关。但是，CRP浓度> 10 mg / l时，观察到风险显着增加：OR（95％CI）4.4（1.8-10.9），在将分析限制为献血后两到五年以上诊断出的病例之后，风险仍然显着（或3.0（1.2-8.0）和3.6（1.0-13.2））。高CRP会增加粘液性肿瘤的风险，但本次分析的病例数很少。结论：研究结果进一步支持了慢性炎症在上皮性卵巢癌中起作用的概念。

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