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首页> 外文期刊>Cancer causes and control: CCC >Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups.
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Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups.

机译：积极的家族史对乳腺癌的诊断，治疗和生存的影响：社会经济群体的不同影响。

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BACKGROUND: This study aims to investigate whether increased awareness of breast cancer, due to a positive family history (FH), reduces diagnostic, therapeutic, and survival differences between women of low versus high socio-economic status (SES). METHODS: All breast cancer patients registered between 1990 and 2005 at the population-based Geneva Cancer Registry were included. With multivariate logistic and Cox regression analysis, we estimated the impact of SES and FH on method of detection, treatment, and mortality from breast cancer. RESULTS: SES discrepancies in method of detection and suboptimal treatment, as seen among women without a FH, disappeared in the presence of a positive FH. SES differences in stage and survival remained regardless of the presence of a positive FH. Overall, positive FH was associated with better survival. This effect was the strongest in women of high SES (age-adjusted Hazard Ratio [HR(ageadj)] 0.54 [0.3-1.0]) but less pronounced in women of middle (0.77 [0.6-1.0]), and absent in women of low SES (0.80 [0.5-1.2]). CONCLUSION: A positive FH of breast cancer may reduce SES differences in access to screening and optimal treatment. However, even with better access to early detection and optimal treatment, women of low SES have higher risks of death from their disease than those of high SES.
机译：背景：这项研究旨在调查由于积极的家族史（FH）而提高对乳腺癌的认识，是否能减少社会经济地位低下（SES）与高社会经济地位（SES）的女性之间的诊断，治疗和生存差异。方法：1990年至2005年间在以人口为基础的日内瓦癌症登记处登记的所有乳腺癌患者均包括在内。通过多因素logistic和Cox回归分析，我们估算了SES和FH对乳腺癌的检测，治疗和死亡率方法的影响。结果：在没有FH的女性中观察到的SES检测方法和次优治疗方法的差异在FH阳性的情况下消失了。不论是否存在阳性FH，SES的分期和生存率差异均保持不变。总体而言，FH阳性与更好的生存率相关。在高SES（年龄调整后的危险比[HR（ageadj）] 0.54 [0.3-1.0]）女性中，这种作用最强，但在中度女性中（0.77 [0.6-1.0]）则不明显，而在中度女性中则没有。低SES（0.80 [0.5-1.2]）。结论：乳腺癌FH阳性可减少SES在筛查和最佳治疗方法上的差异。然而，即使有更好的早期发现和最佳治疗方法，低SES的妇女也比高SES的妇女有更高的死亡风险。

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