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首页> 外文期刊>Cancer causes and control: CCC >Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.
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Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia.

机译：卷曲相关蛋白（FRZB）的遗传变异和结直肠瘤形成的风险。

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OBJECTIVE: The Wnt/APC/beta-catenin signaling pathway, which includes frizzled-related protein (FRZB), plays a critical role in the development of colorectal cancer, and recent evidence suggests that the functional polymorphism, FRZB Arg324Gly, may be associated with risk for this disease. To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies. METHODS: Participants consisted of 1,709 adenoma cases, 620 cancer cases, and 1,849 controls within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations with colorectal neoplasia. RESULTS: No association was observed for either polymorphism or any haplotypes with colorectal adenoma or colorectal cancer (p>0.05 for all). CONCLUSION: Our study does not support the previously observed association between the FRZB 324Gly variant and colorectal cancer risk. However, further study of additional genetic variants within this pathway is still warranted, given the important role of the Wnt signaling pathway in colorectal carcinogenesis.
机译：目的：Wnt / APC /β-catenin信号传导途径包括卷曲相关蛋白（FRZB），在结直肠癌的发展中起关键作用，最近的证据表明功能性多态性FRZB Arg324Gly可能与这种疾病的风险。为了确定是否可以重复此发现，我们在巢式病例对照研究中调查了两个FRZB多态性（Arg324Gly和Arg200Trp）与结直肠腺瘤和癌症风险之间的关联。方法：参与者包括前列腺癌，肺癌，结直肠癌和卵巢癌（PLCO）癌症筛查试验中的1709例腺瘤病例，620例癌症病例和1849例对照。 Logistic回归用于估计与结直肠瘤形成相关的比值比（OR）和95％置信区间（95％CI）。结果：未发现多态性或任何单倍型与大肠腺瘤或大肠癌相关（所有p> 0.05）。结论：我们的研究不支持先前观察到的FRZB 324Gly变体与大肠癌风险之间的关联。然而，鉴于Wnt信号通路在结直肠癌发生中的重要作用，仍然有必要对该通路中的其他遗传变异进行进一步研究。

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