Optical tweezers for drug discovery

Halma M.T.J.; Tuszynski J.A.; Wuite G.J.L.

首页> 外文期刊>Drug discovery today >Optical tweezers for drug discovery

【24h】

Optical tweezers for drug discovery

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

? 2022 The Author(s)The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target ‘undruggable’ proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.

著录项

来源
《Drug discovery today》 |2023年第1期|103443-103443|共6页
作者
Halma M.T.J.; Tuszynski J.A.; Wuite G.J.L.;
展开▼
作者单位

Department of Physics and Astronomy Vrije Universiteit Amsterdam;

Department of Physics University of Alberta;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类药学;
关键词
biological mechanism; conformation; drug discovery; optical tweezers; target identification; undruggable proteins;

相似文献

外文文献
中文文献
专利

1. Optical tweezers and Raman spectroscopy for single‐cell classification of drug resistance in acute lymphoblastic leukemia [J] . Yang Chen, Peifang Jiang, Shuyi LeiXiaoli ChenShuting YaoDongmei JiangDonghong LinXianggang JiaJianda Hu Journal of Biophotonics . 2022,第9期

机译：Optical tweezers and Raman spectroscopy for single‐cell classification of drug resistance in acute lymphoblastic leukemia
2. Label-free cell-based assays with optical biosensors in drug discovery. [J] . Fang Y Assay and drug development technologies . 2006,第5期

机译：Label-free cell-based assays with optical biosensors in drug discovery.
3. Evolution of modern age drug discovery of lipopeptides and computer-aided drug discovery in India [J] . Yadav Manisha, Eswari J. Satya Indian Journal of Biochemistry & Biophysics . 2022,第5期

机译：Evolution of modern age drug discovery of lipopeptides and computer-aided drug discovery in India
4. Ad-optical logic and in a SOA-based Mach-Zehnder am-optical wavelength converter [C] . Byung-Kwon Kang, Jae Hun Kim . 2000

机译：Ad-optical逻辑和基于SOA的Mach-Zehnder am-optical波长转换器
5. Protein-Ligand Docking Application and Comparison Using Discovery Studio and AutoDock [D] . Wang, Qi 2017

机译：蛋白质配体对接应用程序以及使用Discovery Studio和AutoDock进行比较
6. MORPHEEINS – A NEW PATHWAY FOR ALLOSTERIC DRUG DISCOVERY [O] . EILEEN K. JAFFE -1

机译：mORpHEEINs - 一个新的思路变构DRUG DIsCOVERY
7. In silico Approach for Anti-Thrombosis Drug Discovery: P2Y1R Structure-Based TCMs Screening [O] . Fan Yi, Le Sun, Li-jia Xu, 2017

机译：In silico anti-Thrombosis Drug Discovery：基于p2Y1R结构的TCms筛选
8. Origin of the (pi)-Ray/Optical Lags in Luminous Blazars. [R] . Janiak, M., Sikora, M., Nalewajko, K., 2011

机译：发光Blazars中（pi）-Ray / Optical Lags的起源。

Optical tweezers for drug discovery

摘要

著录项

相似文献

相关主题

期刊订阅