The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

Qian X; Li G; Vass WC

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The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

机译：Tensin-3蛋白（包括其SH2结构域）被Src磷酸化，并有助于肿瘤发生和转移。

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In cell lines from advanced lung cancer, breast cancer, and melanoma, endogenous tensin-3 contributes to cell migration, anchorage-independent growth, and tumorigenesis. Although SH2 domains have not been reported previously to be phosphorylated, the tensin-3 SH2 domain is a physiologic substrate for Src. Tyrosines in the SH2 domain contribute to the biological activity of tensin-3, and phosphorylation of these tyrosines can regulate ligand binding. In a mouse breast cancer model, tensin-3 tyrosines are phosphorylated in a Src-associated manner in primary tumors, and experimental metastases induced by tumor-derived cell lines depend on endogenous tensin-3. Thus, tensin-3 is implicated as an oncoprotein regulated by Src and possessing an SH2 domain with a previously undescribed mechanism for the regulation of ligand binding.

机译：在晚期肺癌，乳腺癌和黑素瘤的细胞系中，内源性tensin-3有助于细胞迁移，非锚定生长和肿瘤发生。尽管以前没有报道SH2结构域被磷酸化，但tensin-3 SH2结构域是Src的生理底物。 SH2结构域中的酪氨酸有助于tensin-3的生物学活性，这些酪氨酸的磷酸化可调节配体结合。在小鼠乳腺癌模型中，原发性肿瘤中以Src相关的方式使tensin-3酪氨酸磷酸化，而肿瘤衍生的细胞系诱导的实验转移依赖于内源性tensin-3。因此，tensin-3被认为是一种受Src调控的癌蛋白，具有一个SH2结构域，具有之前未描述的调控配体结合的机制。

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《Cancer Cell》 |2009年第3期|共13页
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Qian X; Li G; Vass WC;
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中图分类肿瘤学;
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1. The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. [J] . Qian X, Li G, Vass WC Cancer Cell . 2009,第3期

机译：Tensin-3蛋白（包括其SH2结构域）被Src磷酸化，并有助于肿瘤发生和转移。
2. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. [J] . Ye G, Ayrapetov M, Nam NH, Bioorganic and Medicinal Chemistry Letters . 2005,第22期

机译：使用EGFP-Src SH2结构域融合蛋白和生物素化Src SH2结构域进行肽的固相结合测定。
3. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. [J] . Ye G, Ayrapetov M, Nam NH, Bioorganic and Medicinal Chemistry Letters . 2005,第22期

机译：使用EGFP-Src SH2结构域融合蛋白和生物素化Src SH2结构域进行肽的固相结合测定。
4. Bio-molecular optimized interactions and conformational switches in human ERβ and SRC-1 protein: An in silico approach to suppress tumor in breast cancer malignancies: Computational insight for suppression of tumorigenesis in breast malignancies [C] . Arundhati Banerjee, Sujay Ray 2016 International Conference on Microelectronics, Computing and Communications . 2016

机译：人类ERβ和SRC-1蛋白中生物分子的优化相互作用和构象转换：抑制乳腺癌恶性肿瘤的计算机方法：抑制乳腺癌恶性肿瘤发生的计算机洞察
5. Structure, kinetics, and backbone dynamics of the SH2 domain of human proto-oncogene protein Vav1 bound to a doubly phosphorylated Syk peptide. [D] . Chen, Chih-Hong. 2011

机译：人原癌基因蛋白Vav1的SH2结构域的结构，动力学和骨架动力学与双磷酸化Syk肽结合。
6. The tensin-3 protein including its SH2 domain is phosphorylated by Src and contributes to tumorigenesis and metastasis [O] . Xiaolan Qian, Guorong Li, William C. Vass, -1

机译：的张力蛋白-3蛋白包括其sH2结构域由src和有助于磷酸化肿瘤发生和转移
7. The Tensin-3 Protein, Including its SH2 Domain, Is Phosphorylated by Src and Contributes to Tumorigenesis and Metastasis [O] . Qian Xiaolan, Li Guorong, Vass William C., 2009

机译：包括其SH2域在内的Tensin-3蛋白被Src磷酸化，并有助于肿瘤发生和转移。
8. Role of Crk Adaptor Proteins in Breast Tumorigenesis and Bone Metastasis. [R] . Bell, E. 2012

机译：Crk衔接蛋白在乳腺肿瘤发生和骨转移中的作用。

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

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