IAP regulation of metastasis.

Mehrotra S; Languino LR; Raskett C

首页> 外文期刊>Cancer Cell >IAP regulation of metastasis.

【24h】

IAP regulation of metastasis.

机译：IAP调节转移。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src. Therefore, IAPs are direct metastasis genes, and their antagonists could provide antimetastatic therapies in patients with cancer.

机译：凋亡抑制蛋白（IAP）有助于肿瘤进展，但尚不清楚该途径的要求。在这里，我们表明XIAP和survivin之间的分子间合作刺激肿瘤细胞入侵并促进转移。该途径独立于IAP对细胞死亡的抑制。取而代之的是，survivin-XIAP复合物激活NF-kappaB，进而导致纤连蛋白基因表达增加，β1整合素发出信号并激活细胞运动性激酶FAK和Src。因此，IAP是直接转移基因，它们的拮抗剂可以为癌症患者提供抗转移疗法。

著录项

来源
《Cancer Cell》 |2010年第1期|共12页
作者
Mehrotra S; Languino LR; Raskett C;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. IAP regulation of metastasis. [J] . Mehrotra S, Languino LR, Raskett C Cancer Cell . 2010,第1期

机译：IAP调节转移。
2. A Particular Case with Long-Term Follow-Up of Rare malignant Hemangiopericytoma of the Lung with Metachronous Diaphragmatic Metastasis. [J] . Brega Massone PP, Lequaglie C, Conti B, The Thoracic and cardiovascular surgeon . 2002,第3期

机译：长期随访罕见的肺癌伴异He上转移的恶性血管周细胞瘤。
3. Transpleurodiaphragmatic radiofrequency thermoablation of a liver metastasis. [J] . Elias D, de-Baere T, Goharin A, Journal of the American College of Surgeons . 2000,第6期

机译：经胸膜ph动脉射频消融治疗肝转移。
4. A Novel Small-Molecule IAP Antagonist, AZD5582, Draws Mcl-1 Down-Regulation for Induction of Apoptosis Through Targeting of cIAP1 and XIAP in Human Pancreatic Cancer [C] . Ih-Yeon Hwang, Seul Lee, Jai-Hee Moon, International Molecular Medicine Tri-Conference. . 2016

机译：一种新型的小分子IAP拮抗剂AZD5582，通过靶向CIAP1和XIAP在人胰腺癌中诱导诱导细胞凋亡的MCL-1下调
5. Regulation of apoptosis by Smac, IAPS, and the ubiquitin proteasome system. [D] . Burke, Stephen P. 2010

机译：Smac，IAPS和泛素蛋白酶体系统对细胞凋亡的调节。
6. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. [O] . R S Warren, H Yuan, M R Matli, 1995

机译：在实验性肝转移的小鼠模型中血管内皮生长因子对人结肠癌肿瘤发生的调控。
7. Thoracoscopic Transdiaphragmatic Approach to Segment VIII Resection as Part of Combination Treatment in a Patient with a Colorectal Liver Metastasis. Case Report [O] . D. V. Podluzhny, M. M. Davydov, E. V. Glukhov, 2020

机译：胸腔镜转椎间椎间素分段分类方法作为结直肠肝转移患者组合治疗的一部分。案例报告
8. MicroRNA Regulation of CD44+ Prostate Tumor Stem/Progenitor Cells and Prostate Cancer Development/Metastasis. [R] . C. Liu 2013

机译：微小RNa调节CD44 +前列腺肿瘤干/祖细胞和前列腺癌发展/转移。

IAP regulation of metastasis.

摘要

著录项

相似文献

相关主题

期刊订阅