p53 mutations and resistance to chemotherapy: A stab in the back for p73.

Soussi T

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p53 mutations and resistance to chemotherapy: A stab in the back for p73.

机译：p53突变和对化疗的抵抗：p73的背部被刺。

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摘要

p73 is essential for apoptosis induced by many cytotoxic agents, but this function can be blocked by a particular category of p53 mutations that have consequently acquired a gain of function.

机译：p73对于许多细胞毒性剂诱导的细胞凋亡至关重要，但是此功能可能会被特定类别的p53突变所阻断，因此该突变已获得功能增强。

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《Cancer Cell》 |2003年第4期|共3页
作者
Soussi T;
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正文语种 eng
中图分类肿瘤学;
关键词
Cancer resistance to treatment; Assault by stabbing; Chemotherapy-Oncologic Procedure; 背;

机译：癌症对治疗的抵抗力;刺伤;化学疗法-肿瘤学程序;背;

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专利

1. p53 mutations and resistance to chemotherapy: A stab in the back for p73. [J] . Soussi T Cancer Cell . 2003,第4期

机译：p53突变和对化疗的抵抗：p73的背部被刺。
2. Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer [J] . Stian Knappskog, Ranjan Chrisanthar, Erik Lokkevik, Breast Cancer Research . 2012,第2期

机译：ATM的低表达水平可能替代CHEK2 / TP53突变，从而预测乳腺癌对蒽环类和丝裂霉素的耐药性
3. TP53 K351N mutation-associated platinum resistance after neoadjuvant chemotherapy in patients with advanced ovarian cancer. [J] . Guo-nan Zhang, Hong Liu, Jian-ming Huang, Gynecologic Oncology: An International Journal . 2014,第3期

机译：TP53 K351N突变与晚期卵巢癌患者新辅助化疗后的铂耐药相关。
4. Efficacy of Radiomics and Genomics in Predicting TP53 Mutations in Diffuse Lower Grade Glioma [C] . Zeina A. Shboul, Khan M. Iftekharuddin Conference on Medical Imaging : Biomedical Applications in Molecular, Structural, and Functional Imaging . 2020

机译：辐射瘤和基因组学在弥漫性较低级胶质瘤中TP53突变预测的疗效
5. Investigations of p53 mutations and effects on drug resistance. [D] . Chan, Kin Tak. 2004

机译：p53突变及其对耐药性影响的研究。
6. Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer [O] . Stian Knappskog, Ranjan Chrisanthar, Erik Løkkevik, 2012

机译：ATM的低表达水平可能替代CHEK2 / TP53突变从而预测乳腺癌对蒽环类和丝裂霉素的耐药性
7. p53 mutations and resistance to chemotherapy: A stab in the back for p73 [O] . Soussi Thierry 2003

机译：p53突变和对化疗的抵抗：p73的背部刺伤

p53 mutations and resistance to chemotherapy: A stab in the back for p73.

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