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NOTch just a bladder control problem

机译：切开只是膀胱控制问题

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Human bladder cancers harbor deletions and point mutations in genes coding for Notch receptors and proteins involved in Notch signaling. This leads to elevated MAPK pathway activation, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost. These bladder tumors, with impaired Notch signaling, also show basal differentiation. Human bladder cancers harbor deletions and point mutations in genes coding for Notch receptors and proteins involved in Notch signaling. This leads to elevated MAPK pathway activation, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost. These bladder tumors, with impaired Notch signaling, also show basal differentiation.
机译：人膀​​胱癌在Notch受体和参与Notch信号传导的蛋白质的编码基因中存在缺失和点突变。这导致升高的MAPK途径激活，因为Notch介导的MAPK磷酸酶DUSP的直接转录丢失。这些Notch信号受损的膀胱肿瘤也显示出基底分化。人膀​​胱癌在Notch受体和参与Notch信号传导的蛋白质的编码基因中存在缺失和点突变。这导致升高的MAPK途径激活，因为Notch介导的MAPK磷酸酶DUSP的直接转录丢失。这些Notch信号受损的膀胱肿瘤也显示出基底分化。

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