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首页> 外文期刊>Cancer Cell >Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia
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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia

机译：急性髓系白血病中间充质转录因子基因FOXC1的频繁抑制。

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Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1 expression in AML was almost exclusively associated with expression of the HOXA/B locus. Functional experiments demonstrated that FOXC1 contributes to a block in monocyte/macrophage differentiation and enhances clonogenic potential. In in vivo analyses, FOXC1 collaborates with HOXA9 to accelerate significantly the onset of symptomatic leukemia. A FOXC1-repressed gene set identified in murine leukemia exhibited quantitative repression in human AML in accordance with FOXC1 expression, and FOXC1(high) human AML cases exhibited reduced morphologic monocytic differentiation and inferior survival. Thus, FOXC1 is frequently derepressed to functional effect in human AML.
机译：通过计算机分析和其他分析，我们确定FOXC1在至少20％的人类AML病例中表达，但在正常的造血人群中没有表达。 AML中的FOXC1表达几乎与HOXA / B基因座的表达相关。功能实验表明，FOXC1有助于阻止单核细胞/巨噬细胞的分化，并增强克隆形成的潜力。在体内分析中，FOXC1与HOXA9协同作用，可显着加速症状性白血病的发作。在小鼠白血病中鉴定出的FOXC1阻遏基因集在人类AML中表现出定量抑制作用，与​​FOXC1表达一致，而在FOXC1（高）人类AML病例中，形态学上单核细胞分化减少且存活时间较低。因此，FOXC1在人AML中经常被抑制以发挥功能作用。

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