Guilty as charged; B-RAF is a human oncogene.

Garnett MJ; Marais R

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Guilty as charged; B-RAF is a human oncogene.

机译：被控有罪; B-RAF是人类致癌基因。

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RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform is mutated at a high frequency in human cancer. Here we review the rapid progress made in our understanding of B-RAF as an oncogene and of its role in cancer.

机译：RAF蛋白是调节细胞对细胞外信号反应的保守信号通路的组成部分。尽管对RAF蛋白的调节和功能进行了20多年的研究，但直到最近才意识到B-RAF同工型在人类癌症中以高频率突变。在这里，我们回顾了我们对B-RAF作为癌基因及其在癌症中的作用的理解方面的快速进展。

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《Cancer Cell》 |2004年第4期|共7页
作者
Garnett MJ; Marais R;
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正文语种 eng
中图分类肿瘤学;
关键词
Oncogenes; Human; Proteins; Malignant Neoplasms; 癌基因; 蛋白质类;

机译：Oncogenes;Human;Proteins;Malignant Neoplasms;癌基因;蛋白质类;

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专利

1. Guilty as charged; B-RAF is a human oncogene. [J] . Garnett MJ, Marais R Cancer Cell . 2004,第4期

机译：被控有罪; B-RAF是人类致癌基因。
2. Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene. [J] . Lee S, Kim JH, Kim H, Immunology: An Official Journal of the British Society for Immunology . 2011,第3期

机译：响应人乳头瘤病毒感染而激活白细胞介素32促炎途径和白细胞介素32的过表达控制人乳头瘤病毒癌基因的表达。
3. Guilty as Charged [J] . Genetic Engineering & Biotechnology News: The Information Source of the Biotechnology Industry . 2020,第2期

机译：被指控有罪
4. Guilty or not guilty? human factors structured methods on trial [C] . John Long, Simon Hakiel, Leela Damodoran, Conference companion on Human factors in computing systems . 1994

机译：有罪还是无罪？人为因素构造的审判方法
5. Super-charged NK cells increase immune infiltration in the tumor microenvironment and inhibit tumor growth in humanized-BLT mice. [D] . Kaur, Kawaljit. 2017

机译：荷电的NK细胞增加了肿瘤微环境中的免疫浸润，并抑制了人源化BLT小鼠的肿瘤生长。
6. Erythropoiesis-Stimulating Agent Hyporesponsiveness and Adverse Outcomes: Guilty as Charged? [O] . Jay B. Wish 2020

机译：促红细胞生成刺激剂低响应性和不良结果：收费有罪吗？
7. Guilty as charged B-RAF is a human oncogene [O] . Garnett Mathew J., Marais Richard 2004

机译：B-RAF罪名成立是人类致癌基因

Guilty as charged; B-RAF is a human oncogene.

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