...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Cell >Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
【24h】

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.

机译：骨膜素通过通过Akt / PKB途径增加细胞存活力来有效地促进结肠癌的转移性生长。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the alpha(v)beta(3) integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.
机译：与肿瘤转移相关的分​​子机制仍知之甚少。在这里我们报告说，结肠癌细胞获得的骨膜素表达大大促进了结肠肿瘤的转移发展。在超过80％的人类结肠癌中，骨膜素过表达，在转移性肿瘤中表达最高。骨膜蛋白表达通过防止癌细胞中应激诱导的凋亡和增加内皮细胞存活率来促进血管生成，从而显着增强结肠癌的转移性生长。在分子水平上，骨膜素通过α（v）beta（3）整合素激活Akt / PKB信号通路，以增加细胞存活率。这些数据表明存活促进功能对于骨膜素促进结肠癌的肿瘤转移至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号