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首页> 外文期刊>Cancer Cell >CUTL1 is a target of TGFbeta signaling that enhances cancer cell motility and invasiveness.
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CUTL1 is a target of TGFbeta signaling that enhances cancer cell motility and invasiveness.

机译：CUTL1是TGFbeta信号转导的靶标，可增强癌细胞的运动性和侵袭性。

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摘要

CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo. Furthermore, we identify CUTL1 as a transcriptional target of transforming growth factor beta and a mediator of its promigratory effects. CUTL1 activates a transcriptional program regulating genes involved in cell motility, invasion, and extracellular matrix composition. CUTL1 expression is significantly increased in high-grade carcinomas and is inversely correlated with survival in breast cancer. This suggests that CUTL1 plays a central role in coordinating a gene expression program associated with cell motility and tumor progression.
机译：CUTL1，也称为CDP，Cut或Cux-1，是一个同源域转录调节因子，已知参与发育和细胞周期进程。在这里，我们报告CUTL1活性与大量的体外和体内肿瘤细胞迁移和侵袭性相关。此外，我们将CUTL1识别为转化生长因子β的转录靶点及其转移效应的介体。 CUTL1激活一个转录程序，调节与细胞运动，侵袭和细胞外基质组成有关的基因。 CUTL1表达在高级别癌中显着增加，并且与乳腺癌的生存率呈负相关。这表明CUTL1在协调与细胞运动性和肿瘤进展相关的基因表达程序中起着核心作用。

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