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首页> 外文期刊>Cancer Cell >Pregnancy and breast cancer: the other side of the coin.
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Pregnancy and breast cancer: the other side of the coin.

机译：怀孕和乳腺癌：硬币的另一面。

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摘要

Early full-term pregnancy is thought to be one of the most effective means of decreasing lifetime breast cancer risk. Paradoxically, young women diagnosed with breast cancer shortly after giving birth have a higher risk of dying from their disease. These seemingly opposing effects have been largely attributed to mammary epithelial stem cell differentiation and precancerous cell proliferation, respectively, induced by pregnancy-associated hormonal changes. However, recent studies suggest that remodeling of the cellular microenvironment and extracellular matrix during pregnancy and involution may contribute to the enhanced invasive and metastatic potential of breast carcinomas and thus lead to their worse clinical outcome.
机译：早期足月妊娠被认为是降低终生乳腺癌风险的最有效手段之一。矛盾的是，刚出生后不久被诊断出患有乳腺癌的年轻妇女死于疾病的风险更高。这些看似相反的作用在很大程度上分别归因于与妊娠有关的激素变化引起的乳腺上皮干细胞分化和癌前细胞增殖。然而，最近的研究表明，怀孕和复旧过程中细胞微环境和细胞外基质的重塑可能有助于增强乳腺癌的浸润和转移潜能，从而导致其较差的临床结果。

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