Mouse models of human cancer as tools in drug development.

Holland EC

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Mouse models of human cancer as tools in drug development.

机译：作为药物开发工具的人类癌症小鼠模型。

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Histologically accurate mouse models of human cancers generated by somatic or germline genetic modification strategies recapitulate the genetic alterations found in human tumors. In this issue of Cancer Cell, test a novel signaling inhibitor in a genetically defined mouse medulloblastoma and show the utility of these models in drug development. They demonstrate that targeting signaling components downstream of tumor initiating mutations can be an effective therapeutic strategy for solid tumors.

机译：通过体细胞或种系遗传修饰策略生成的人类癌症的组织学精确小鼠模型概括了人类肿瘤中发现的遗传改变。在本期《癌细胞》中，在基因定义的小鼠髓母细胞瘤中测试新型信号抑制剂，并展示这些模型在药物开发中的实用性。他们证明，靶向肿瘤起始突变下游的信号传导成分可以是实体瘤的有效治疗策略。

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《Cancer Cell》 |2004年第3期|共2页
作者
Holland EC;
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正文语种 eng
中图分类肿瘤学;
关键词
Human; drug development; Malignant Neoplasms; Genetic; Laboratory mice;

机译：人;药物开发;恶性肿瘤;遗传;实验室小鼠;

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专利

1. Mouse models of human cancer as tools in drug development. [J] . Holland EC Cancer Cell . 2004,第3期

机译：作为药物开发工具的人类癌症小鼠模型。
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4. Discovery of Human Prostate Cancer Biomarkers From a Xenograft Mouse Model and Formalin-fixed, Paraffin-embedded Prostate Cancer Tissue [C] . Hsin-Yao Tang, Lynn Beer, Tony Chang-Wong, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

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5. Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs: Pharmacological Evaluation in Phenotypically Diverse Breast Cancer Models and Pharmacokinetic Assessment in Liver Microsome and Female Mouse Models [D] . Hasan, Mahmud. 2020

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6. Mouse Models of Human Bladder Cancer as a Tool for Drug Discovery [O] . Catherine Seager, Anna M. Puzio-Kuter, Carlos Cordon-Cardo, -1

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7. Mouse models of human cancer as tools in drug development [O] . Holland Eric C. 2004

机译：人类癌症的小鼠模型作为药物开发的工具

Mouse models of human cancer as tools in drug development.

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