Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

Tan C; Cruet Hennequart S; Troussard A; Fazli L; Costello P; Sutton K; Wheeler J; Gleave M; Sanghera J; Dedhar S

首页> 外文期刊>Cancer Cell >Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

【24h】

Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

机译：整联蛋白连接激酶（ILK）调节肿瘤血管生成。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We show that integrin-linked kinase (ILK) stimulates the expression of VEGF by stimulating HIF-1alpha protein expression in a PKB/Akt- and mTOR/FRAP-dependent manner. In human prostate cancer cells, knockdown of ILK expression with siRNA, or inhibition of ILK activity, results in significant inhibition of HIF-1alpha and VEGF expression. In endothelial cells, VEGF stimulates ILK activity, and inhibition of ILK expression or activity results in the inhibition of VEGF-mediated endothelial cell migration, capillary formation in vitro, and angiogenesis in vivo. Inhibition of ILK activity also inhibits prostate tumor angiogenesis and suppresses tumor growth. These data demonstrate an important and essential role of ILK in two key aspects of tumor angiogenesis: VEGF expression by tumor cells and VEGF-stimulated blood vessel formation.

机译：我们显示整联蛋白连接激酶（ILK）通过以PKB / Akt-和mTOR / FRAP依赖性方式刺激HIF-1alpha蛋白表达来刺激VEGF的表达。在人类前列腺癌细胞中，用siRNA抑制ILK表达或抑制ILK活性会导致HIF-1alpha和VEGF表达的显着抑制。在内皮细胞中，VEGF刺激ILK活性，抑制ILK表达或活性可抑制VEGF介导的内皮细胞迁移，体外毛细血管形成和体内血管生成。 ILK活性的抑制还抑制前列腺肿瘤血管生成并抑制肿瘤生长。这些数据证明了ILK在肿瘤血管生成的两个关键方面的重要作用：肿瘤细胞的VEGF表达和VEGF刺激的血管形成。

著录项

来源
《Cancer Cell》 |2004年第1期|共12页
作者
Tan C; Cruet Hennequart S; Troussard A; Fazli L; Costello P; Sutton K; Wheeler J; Gleave M; Sanghera J; Dedhar S;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Endothelial Cells; Neovascularization; Pathologic; Protein-Serine-Threonine Kinases; 新生血管化; 病理性; 蛋白质丝氨酸苏氨酸激酶; 转录因子;

机译：Endothelial Cells;Neovascularization;Pathologic;Protein-Serine-Threonine Kinases;新生血管化;病理性;蛋白质丝氨酸苏氨酸激酶;转录因子;

相似文献

外文文献
中文文献
专利

1. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). [J] . Tan C, Cruet Hennequart S, Troussard A, Cancer Cell . 2004,第1期

机译：整联蛋白连接激酶（ILK）调节肿瘤血管生成。
2. 61 Mutant-PTEN leads to constitutive integrin-linked kinase (ILK) activity that regulates PKB/Akt activity in glioblastoma cancer cells and targeting ILK results in tumor growth-delay in vivo [J] . L.Edwards, B.Thiessen, V.Dragowska, European Journal of Cancer Supplements . 2004,第8期

机译：61突变体PTEN导致组成性整合素连接激酶（ILK）活性调节胶质母细胞瘤癌细胞中的PKB / Akt活性并靶向ILK导致体内肿瘤生长延迟
3. 61 Mutant-PTEN leads to constitutive integrin-linked kinase (ILK) activity that regulates PKB/Akt activity in glioblastoma cancer cells and targeting ILK results in tumor growth-delay in vivo [J] . L.Edwards, B.Thiessen, V.Dragowska, European Journal of Cancer Supplements . 2004,第8期

机译：61突变体PTEN导致组成性整合素连接激酶（ILK）活性调节胶质母细胞瘤癌细胞中的PKB / Akt活性并靶向ILK导致体内肿瘤生长延迟
4. Biphasic Regulation of H_2O_2 on Angiogenesis and Natural Antioxidant Pedicularioside G Inhibits Angiogenesis and Tumorigenesis in vitro and in vivo [C] . P. Mu, Q. Liu, X. Gao, Society for Free Radical Research International . 2008

机译：H_2O_2对血管生成和天然抗氧化梗皂甙G的双相调节抑制体外和体外血管生成和肿瘤内酯
5. Dysregulation of integrin-linked kinase (ILK) signaling during colorectal carcinogenesis: Modulation of signaling pathways by non-steroidal anti-inflammatory drugs (NSAID). [D] . Marotta, Anthony. 2002

机译：大肠癌发生过程中整合素连接激酶（ILK）信号的失调：非甾体抗炎药（NSAID）对信号通路的调节。
6. Integration of Cell Attachment Cytoskeletal Localization and Signaling by Integrin-linked Kinase (ILK) CH-ILKBP and the Tumor Suppressor PTEN [O] . Sarah Attwell, Julia Mills, Armelle Troussard, 2003

机译：整合的细胞附着细胞骨架定位和整合素联激酶（ILK）CH-ILKBP和肿瘤抑制因子PTEN的信号传导。
7. Regulation of tumor angiogenesis by integrin-linked kinase (ILK) [O] . Tan Clara, Cruet-Hennequart Severine, Troussard Armelle, 2004

机译：整合素连接激酶（ILK）调节肿瘤血管生成
8. Role of the Integrin-Linked Kinase (ILK) in Mammary Gland Tumorigenesis and Metastasis [R] . White, D. E. 2002

机译：整合素连接激酶（ILK）在乳腺肿瘤发生和转移中的作用

Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

摘要

著录项

相似文献

相关主题

期刊订阅