Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy

Leone Robert D.; Horton Maureen R.; Powell Jonathan D.

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Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy

机译：空气中的某些东西：肿瘤微环境的高氧调节以增强免疫治疗

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Recent clinical trials in cancer therapy have demonstrated unprecedented responses through blockade of CTLA-4 and PD-1 immune checkpoint pathways. In a provocative recent paper in Science Translational Medicine, Hatfield and colleagues demonstrate the ability of supplemental oxygen to act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.

机译：最近在癌症治疗中进行的临床试验表明，通过阻断CTLA-4和PD-1免疫检查点途径，空前的反应。 Hatfield及其同事在《科学转化医学》（Science Translational Medicine）的近期一篇引人入胜的论文中证明了补充氧气能够通过破坏缺氧-腺苷-A2aR途径来充当新型免疫检查点抑制剂。

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《Cancer Cell》 |2015年第4期|共2页
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Leone Robert D.; Horton Maureen R.; Powell Jonathan D.;
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正文语种 eng
中图分类肿瘤学;
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1. Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy [J] . Leone Robert D., Horton Maureen R., Powell Jonathan D. Cancer Cell . 2015,第4期

机译：空气中的某些东西：肿瘤微环境的高氧调节以增强免疫治疗
2. Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy through Regulating Tumor Microenvironment [J] . Ming-Cheng Chang, Yu-Li Chen, Han-Wei Lin, Molecular therapy: the journal of the American Society of Gene Therapy . 2018,第2期

机译：通过调节肿瘤微环境提高抗原特异性免疫疗法的噬菌体抗肿瘤作用
3. Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy [J] . Qian Chen, Ligeng Xu, Jiawen Chen, Biomaterials . 2017,第期

机译：口服欧洲血管毒素的肿瘤血管系统标准化以调节肿瘤微环境，用于增强癌症纳米医生和免疫疗法
4. Differential Proteomic Analysis of Hypoxic Tumor Microenvironment in vivo in Fibrosarcoma Inoculated Mice Breathing Atmospheric or Hyperoxic Oxygen [C] . Shujia Dai, Kengo Moriyama, Dmitriy Lukashev, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：体内缺氧肿瘤微环境的差异蛋白质组学分析瘘管呼吸大气或高氧氧气的纤维瘤犬小鼠
5. The Immune Checkpoint B7x Promotes the Induction of Regulatory T Cells in the Tumor Microenvironment and Mediates Resistance to Immunotherapy [D] . John, Peter. 2022

机译：免疫检查点B7X促进肿瘤微环境中调节性T细胞的诱导，并介导对免疫疗法的抗性
6. Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy [O] . Robert D. Leone, Maureen R. Horton, Jonathan D. Powell -1

机译：空气中的某些东西：肿瘤微环境的高氧调节以增强免疫治疗
7. Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy [O] . Leone Robert D., Horton Maureen R., Powell Jonathan D. 2015

机译：空气中的某些东西：增强免疫疗法的肿瘤微环境的高氧调节

Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy

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