Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.

Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y

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Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.

机译：Pten限制了胰腺的人椎突肌细胞扩张和恶性转化。

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To determine the role of the phosphatidylinositol 3-kinase (PI3-K) pathway in pancreas development, we generated a pancreas-specific knockout of Pten, a negative regulator of PI3-K signaling. Knockout mice display progressive replacement of the acinar pancreas with highly proliferative ductal structures that contain abundant mucins and express Pdx1 and Hes1, two markers of pancreatic progenitor cells. Moreover, a fraction of these mice develop ductal malignancy. We provide evidence that ductal metaplasia results from the expansion of centroacinar cells rather than transdifferentiation of acinar cells. These results indicate that Pten actively maintains the balance between different cell types in the adult pancreas and that misregulation of the PI3-K pathway in centroacinar cells may contribute to the initiation of pancreatic carcinoma in vivo.

机译：为了确定磷脂酰肌醇3-激酶（PI3-K）通路在胰腺发育中的作用，我们产生了胰腺特异性的Pten基因敲除，PI3-PI信号的负调控子。敲除小鼠显示出腺泡胰腺逐渐被高度增生的导管结构所取代，该导管结构含有丰富的粘蛋白并表达Pdx1和Hes1，这是胰腺祖细胞的两个标志物。此外，这些小鼠中有一部分会发展为导管恶性肿瘤。我们提供的证据表明，导管上皮化生是由腺泡细胞的扩增而不是腺泡细胞的转分化所致。这些结果表明，Pten可以在成年胰腺中活跃地维持不同细胞类型之间的平衡，并且在中心腺泡细胞中PI3-K通路的失调可能在体内引发胰腺癌。

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《Cancer Cell》 |2005年第3期|共11页
作者
Stanger BZ; Stiles B; Lauwers GY; Bardeesy N; Mendoza M; Wang Y; Greenwood A; Cheng KH; McLaughlin M; Brown D; Depinho RA; Wu H; Melton DA; Dor Y;
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正文语种 eng
中图分类肿瘤学;
关键词
Pancreas; Malignant Neoplasms; Pancreatic polypeptide; avian; 胰腺;

机译：胰腺;恶性肿瘤;胰多肽;禽类;胰腺;

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专利

1. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. [J] . Stanger BZ, Stiles B, Lauwers GY, Cancer Cell . 2005,第3期

机译：Pten限制了胰腺的人椎突肌细胞扩张和恶性转化。
2. Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation [J] . BurgerM.L., XueL., SunY., Blood: The Journal of the American Society of Hematology . 2014,第26期

机译：预先缺乏的PTEN缺乏型胸腺细胞激活MicroRNAS miR-146a和miR-146b作为对恶性转化的细胞防御
3. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes [J] . David K. Finlay, Linda V. Sinclair, Carmen Feijoo, The Journal of Experomental Medicine . 2009,第11期

机译：磷酸肌醇依赖性激酶1控制迁移和恶性转化，但不控制PTEN无效淋巴细胞中的细胞生长和增殖
4. Pten and p53 Converge on c-Myc to Control Differentiation,Self-renewal, and Transformation of Normal and NeoplasticStem Cells in Glioblastoma [C] . H. ZHENG, H.YING, H.YAN, Cold Harbor Symposium on Quantitative Biology . 2008

机译：PTEN和P53汇集了C-MYC以控制胶质母细胞瘤中正常和肿瘤系统细胞的分化，自我更新和转化
5. Antigen receptor-derived signals in B cells: Comparative biology of malignant and non-malignant CD5+ B cells and implications for malignant pathogenesis. [D] . Bernal, Alejandro. 2002

机译：B细胞中抗原受体衍生的信号：恶性和非恶性CD5 + B细胞的比较生物学及其对恶性发病机制的影响。
6. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes [O] . David K. Finlay, Linda V. Sinclair, Carmen Feijoo, 2009

机译：磷酸肌醇依赖性激酶1控制迁移和恶性转化但不控制PTEN无效淋巴细胞中的细胞生长和增殖
7. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas [O] . Stanger Ben Z., Stiles Bangyan, Lauwers Gregory Y., 2005

机译：Pten限制胰腺中的人椎突肌细胞扩张和恶性转化

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.

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