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首页> 外文期刊>Microbiology and Immunology >Cytokine profiles in chickens infected with virulent and avirulent Marek's disease viruses: Interferon-gamma is a key factor in the protection of Marek's disease by vaccination
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Cytokine profiles in chickens infected with virulent and avirulent Marek's disease viruses: Interferon-gamma is a key factor in the protection of Marek's disease by vaccination

机译：感染了毒性和无毒马立克氏病病毒的鸡的细胞因子谱：γ-干扰素是通过疫苗预防马立克氏病的关键因素

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Marek's disease has been controlled by vaccination with avirulent strains of MDV. However, the protection mechanism following vaccination is not fully understood. In this study immune responses of PBMC and splenocytes derived from vaccinated chickens challenged with virulent MDV were examined using real-time PCR and ELISA. Higher levels of IFN-gamma induction were observed in chickens vaccinated during the latent phase of infection with virulent MDV than in similarly challenged, unvaccinated chickens. Furthermore, the mean expression of IFNGR2 and IFN regulatory factor-3 mRNAs was significantly higher in vaccinated than in unvaccinated chickens. These results show that IFN-gamma could be one of the important factors in prevention of MD by vaccination and is effective during the latent phase of the infection.
机译：马立克氏病已通过接种无毒的MDV株进行了控制。但是，疫苗接种后的保护机制尚未完全了解。在这项研究中，使用实时PCR和ELISA检测了用强毒MDV攻击的接种鸡的PBMC和脾细胞的免疫反应。在强毒MDV的潜伏期接种疫苗的鸡中观察到的IFN-γ诱导水平高于未接种类似疫苗的鸡。此外，接种疫苗的鸡中IFNGR2和IFN调节因子-3 mRNA的平均表达明显高于未接种鸡。这些结果表明，IFN-γ可能是通过疫苗预防MD的重要因素之一，并且在感染的潜伏期有效。

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