...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Metabolic brain disease >Neonatal maternal separation affects endocrine and metabolic stress responses to ether exposure but not to restraint exposure in adult rats.
【24h】

Neonatal maternal separation affects endocrine and metabolic stress responses to ether exposure but not to restraint exposure in adult rats.

机译：新生儿母体分离影响成年大鼠对乙醚暴露的内分泌和代谢应激反应，但不影响成年大鼠的内分泌和代谢应激反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigated prolactin secretion and metabolic changes in stress response in adult male rats submitted to periodic maternal separation (MS; 180 min/day) at 2 weeks of life. Restraint and ether exposure were randomly performed when the animals were 10-12 weeks of age. Restraint exposure: the animals were placed into plastic tubes (21 cm long, 4.5 cm diameter) for 20 min. Ether exposure: the rats were exposed to ether for 10 min. Atrial cannulation for blood sampling was performed through the jugular vein 5 days before the experiments. In both protocols, blood samples were taken immediately before (0), and 5, 15 and 20 min after the beginning of stress exposure. Ours results showed attenuated endocrine and metabolic responses to ether exposure in the maternal separation (MS) group compared to the control group. The measured metabolic parameters, plasma glucose, prolactin, lactate, and insulin secretion, were 32%, 55%, 41%, 73% lower (P < 0.01), respectively, in MS than in control animals. On the otherhand, the endocrine and metabolic stress responses to restraint exposure were not affected by maternal separation. There was no difference between the MS and the control groups in any of the parameters studied. Our data demonstrated that early life experiences affect the hormonal systems beyond the hypothalamic-pituitary-adrenal axis, such as the central neuronal pathways, and their activities related to hormonal and metabolic responses to stress in adulthood. More importantly, these modifications were specific, but dependent on stress situation affecting mainly the circuitry related to the stress response to ether exposure.
机译：我们调查了生命周期为2周的定期母体分离（MS; 180分钟/天）的成年雄性大鼠的催乳激素分泌和应激反应的代谢变化。当动物为10-12周大时，随机进行约束和乙醚暴露。约束暴露：将动物放入塑料管（长21厘米，直径4.5厘米）中20分钟。乙醚暴露：将大鼠暴露于乙醚10分钟。实验前5天，通过颈静脉进行心房插管采血。在这两种方案中，均应在压力暴露开始之前（0）以及开始暴露后5、15和20分钟采集血样。我们的研究结果显示，与对照组相比，母体分离（MS）组中内分泌和代谢对乙醚暴露的反应减弱。 MS中测得的代谢参数，血浆葡萄糖，催乳素，乳酸盐和胰岛素分泌分别比对照动物低32％，55％，41％，73％（P <0.01）。另一方面，母体分离对约束性暴露的内分泌和代谢应激反应没有影响。 MS和对照组之间在所研究的任何参数上均无差异。我们的数据表明，早期生活经历会影响下丘脑-垂体-肾上腺轴以外的激素系统，例如中枢神经元通路，其活动与成年期对压力的激素和代谢反应有关。更重要的是，这些修饰是特定的，但取决于应力情况，该情况主要影响与对醚暴露的应力响应有关的电路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号