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首页> 外文期刊>Cancer causes and control: CCC >An investigation of the biological basis of an interaction of abdominal fat distribution and family history of breast cancer. A nested study of sisters in the Iowa Women's Health Study (United States).
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An investigation of the biological basis of an interaction of abdominal fat distribution and family history of breast cancer. A nested study of sisters in the Iowa Women's Health Study (United States).

机译：腹部脂肪分布与乳腺癌家族史相互作用的生物学基础研究。爱荷华州妇女健康研究（美国）中姐妹的嵌套研究。

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OBJECTIVE: The present study examined whether levels of testosterone, sex hormone binding globulin (SHBG), or insulin levels might underlie an increased risk of postmenopausal breast cancer in women with both high waist-to-hip ratio and a family history of breast cancer disease that was noted earlier in the Iowa Women's Health Study. METHODS: Participants for the current study were selected from 1922 sister groups (3978 women) in the Iowa Women's Health Study cohort. Two groups were included: (1) those with no family history of breast cancer and at least one sister with a high waist-to-hip ratio; or (2) those with a positive family history of breast cancer and at least one sister with a high waist-to-hip ratio. Testosterone, SHBG and insulin were measured by radioimmunoassay from 245 fasting blood samples. RESULTS: Familial correlations among members of 66 families were estimated at 0.32, 0.28 and 0.25 for serum insulin, free testosterone and SHBG; respectively. Fasting serum insulin was significantly higher in breast cancer family history negative women than in family history positive women, in direct opposition to our a priori hypothesis. No significant differences were observed in serum SHBG or free testosterone across family history categories. CONCLUSION: This study corroborates a genetic component to fasting serum insulin, free testosterone and SHBG levels. It seems unlikely that insulin, SHBG, or testosterone explain the interaction between waist-to-hip ratio and family history of breast cancer among participants in the Iowa Women's Health Study.
机译：目的：本研究调查了高腰臀比和有乳腺癌家族病史的妇女绝经后乳腺癌风险增加是睾丸激素，性激素结合球蛋白（SHBG）或胰岛素水平升高的原因爱荷华州妇女健康研究前面已经提到了这一点。方法：本研究的参与者选自爱荷华州妇女健康研究队列中的1922个姐妹小组（3978名妇女）。包括两组：（1）没有乳腺癌家族史且至少一个姐姐的腰臀比例高的人;或（2）乳腺癌家族史阳性的人和至少一个姐姐的腰臀比例高。通过放射免疫法从245个空腹血样中测量睾丸激素，SHBG和胰岛素。结果：66个家庭成员的血清胰岛素，游离睾丸激素和SHBG的家族相关性估计为0.32、0.28和0.25。分别。与我们的先验假设直接相反，乳腺癌家族史阴性女性的空腹血清胰岛素显着高于家族史阳性女性。在家族史类别中，血清SHBG或游离睾丸激素未见明显差异。结论：本研究证实了空腹血清胰岛素，游离睾丸激素和SHBG水平的遗传成分。爱荷华州妇女健康研究的参与者中，胰岛素，SHBG或睾丸激素似乎无法解释腰臀比与乳腺癌家族史之间的相互作用。

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