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首页> 外文期刊>Cancer Cell >Genes that distinguish physiological and pathological angiogenesis.
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Genes that distinguish physiological and pathological angiogenesis.

机译：区分生理和病理血管生成的基因。

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To unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the blood vessels of eight normal resting tissues, five tumors, and regenerating liver. Organ-specific endothelial genes were readily identified, including 27 from brain. We also identified 25 transcripts overexpressed in tumor versus normal endothelium, including 13 that were not found in the angiogenic endothelium of regenerating liver. Most of the shared angiogenesis genes have expected roles in cell-cycle control, but those specific for tumor endothelium were primarily cell surface molecules of uncertain function. These studies reveal striking differences between physiological and pathological angiogenesis potentially important for the development of tumor-specific, vascular-targeted therapies.
机译：为了弄清正常血管系统的转录组并确定其如何被邻近的恶性细胞改变，我们比较了来自八种正常静息组织，五种肿瘤和再生肝脏的血管内皮细胞的基因表达模式。器官特异性内皮基因很容易被鉴定出来，其中包括来自大脑的27种。我们还确定了与正常内皮相比在肿瘤中过表达的25个转录物，包括在再生肝的血管生成内皮中未发现的13个转录物。大多数共享的血管生成基因在细胞周期控制中具有预期的作用，但是对肿瘤内皮特异的那些主要是功能不确定的细胞表面分子。这些研究揭示了生理性和病理性血管生成之间的惊人差异，这对于开发肿瘤特异性，针对血管的疗法可能具有重要意义。

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