Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.

Memarzadeh S; Xin L; Mulholland DJ; Mansukhani A; Wu H; Teitell MA; Witte ON

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Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.

机译：旁分泌FGF10表达的增强促进了多灶性前列腺腺癌的形成和上皮雄激素受体的增加。

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Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype. A subset of the FGF10-induced carcinoma was serially transplantable. Paracrine FGF10 led to an increase in epithelial androgen receptor and synergized with cell-autonomous activated AKT. Our observations indicate that stromal FGF10 expression may facilitate the multifocal histology observed in prostate adenocarcinoma and suggest the FGF10/FGFR1 axis as a potential therapeutic target in treating hormone-sensitive or refractory prostate cancer. We also show that transient exposure to a paracrine growth factor may be sufficient for the initiation of oncogenic transformation.

机译：FGF10的间充质表达增强导致多灶性PIN或前列腺癌的形成。使用DN FGFR1抑制上皮FGFR1信号传导会导致癌症表型的逆转。 FGF10诱导的癌的一个子集可以串行移植。旁分泌FGF10导致上皮雄激素受体增加，并与细胞自主激活的AKT协同作用。我们的观察结果表明基质FGF10表达可能促进在前列腺腺癌中观察到的多灶性组织学，并提示FGF10 / FGFR1轴是治疗激素敏感性或难治性前列腺癌的潜在治疗靶标。我们还表明，短暂暴露于旁分泌生长因子可能足以引发致癌转化。

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《Cancer Cell》 |2007年第6期|共14页
作者
Memarzadeh S; Xin L; Mulholland DJ; Mansukhani A; Wu H; Teitell MA; Witte ON;
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正文语种 eng
中图分类肿瘤学;
关键词
Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cell Transformation; Neoplastic; 动物; 细胞分化; 细胞存活; 细胞转化; 肿瘤; 酶激活; 上皮细胞; 上皮; 基因; 显性;

机译：Animals;Cell Differentiation;Cell Proliferation;Cell Survival;Cell Transformation;Neoplastic;动物;细胞分化;细胞存活;细胞转化;肿瘤;酶激活;上皮细胞;上皮;基因;显性;

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1. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. [J] . Memarzadeh S, Xin L, Mulholland DJ, Cancer Cell . 2007,第6期

机译：旁分泌FGF10表达的增强促进了多灶性前列腺腺癌的形成和上皮雄激素受体的增加。
2. Id-1 expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen receptor. [J] . Sun Yinghao, Tang Gusheng, Xu Chuanliang, Cancer letters . 2009,第2期

机译：在雄激素依赖性前列腺癌中，Id-1表达受雄激素通过雄激素受体的负调控。
3. Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10 [J] . Petra EA Huijts, Minka van Dongen, Moniek CM de Goeij, Breast Cancer Research . 2011,第4期

机译：FGFR2表达的等位基因特异性调节取决于细胞类型，并可能通过涉及FGF10的旁分泌刺激而增加乳腺癌风险
4. AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer [C] . Margarita Mikhailova, Yu Wang, Roble Bedolia, International Symposium on Hormonal Carcinogenesis . 2008

机译：AKT调节前列腺癌中的雄激素受体依赖性生长和PSA表达
5. Therapeutic Targeting of Stat5a/b in Advanced Prostate Cancer: Inhibition of Stat5a/b Suppresses Growth of Prostate Cancer through Mechanisms Dependent and Independent of Androgen Receptor. [D] . Hoang, David Timothy. 2016

机译：Stat5a / b在晚期前列腺癌中的治疗靶点：Stat5a / b的抑制作用通过依赖于雄激素受体的机制来抑制前列腺癌的生长。
6. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor [O] . Sanaz Memarzadeh, Li Xin, David J. Mulholland, -1

机译：旁分泌FGF10表达的增强促进了多灶性前列腺腺癌的形成并增加了上皮雄激素受体
7. Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in Epithelial Androgen Receptor [O] . Memarzadeh Sanaz, Xin Li, Mulholland David J., 2007

机译：增强旁分泌FGF10表达促进多灶性前列腺腺癌的形成和上皮雄激素受体的增加。
8. Human Plasma Enhances the Expression of Staphylococcal Microbial Surface Components Recognizing Adhesive Matrix Molecules Promoting Biofilm Formation and Increases Antimicrobial Tolerance In Vitro. [R] . Cardile, A. P., Sanchez, J., Samberg, M. E., 2014

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Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.

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