A novel role for a familiar protein in apoptosis induced by proteasome inhibition.

McConkey DJ

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A novel role for a familiar protein in apoptosis induced by proteasome inhibition.

机译：熟悉的蛋白质在蛋白酶体抑制诱导的细胞凋亡中的新作用。

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In this issue of Cancer Cell, Nickeleit et al. (2008) identify a new proteasome inhibitor, argyrin A, and show that it induces apoptosis and inhibits angiogenesis via p27-dependent mechanisms. Their observations challenge current thinking about how this class of promising cancer therapies works and why they selectively kill cancer cells.

机译：在本期《癌细胞》中，Nickeleit等人。（2008年）确定了一种新的蛋白酶体抑制剂，精氨酸A，并表明它通过依赖p27的机制诱导细胞凋亡并抑制血管生成。他们的观察结果挑战了当前关于这类有前途的癌症疗法如何起作用以及为何选择性杀死癌细胞的想法。

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《Cancer Cell》 |2008年第1期|共2页
作者
McConkey DJ;
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正文语种 eng
中图分类肿瘤学;
关键词
Angiogenesis Inhibitors; Animals; Apoptosis; Blood Vessels; Boronic Acids; 动物; 脱噬作用; 血管; 硼酸化物; 细胞周期; 半胱氨酸蛋白酶抑制剂; 剂量效应关系; 药物;

机译：Angiogenesis Inhibitors;Animals;Apoptosis;Blood Vessels;Boronic Acids;动物;脱噬作用;血管;硼酸化物;细胞周期;半胱氨酸蛋白酶抑制剂;剂量效应关系;药物;

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1. A novel role for a familiar protein in apoptosis induced by proteasome inhibition. [J] . McConkey DJ Cancer Cell . 2008,第1期

机译：熟悉的蛋白质在蛋白酶体抑制诱导的细胞凋亡中的新作用。
2. Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase C|[delta]| [J] . H Yan, Y-C Wang, D Li, Leukemia . 2007,第7期

机译：三氧化二砷和蛋白酶体抑制剂硼替佐米协同诱导白血病细胞凋亡：蛋白激酶C |δ|的作用
3. Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. [J] . Nickeleit I, Zender S, Sasse F, Cancer Cell . 2008,第1期

机译：精蛋白a揭示了抑癌蛋白p27（kip1）在介导对蛋白酶体抑制的抗肿瘤活性中的关键作用。
4. Arsenic trioxide induces both apoptosis and autophagy through stimulation of ER stress and inhibition of ubiquitin-proteasome system in human sarcoma cells [C] . H.-W. Chiu, Y.-C. Tseng, Y.-J. Wang International Congress on Arsenic in the Environment . 2014

机译：通过刺激人类肉瘤细胞中的ER应激和泛素 - 蛋白酶体系的ER应激和抑制来诱导细胞凋亡和自噬
5. Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line. [D] . Butler, Kristie Lynn. 2014

机译：Bcl-2蛋白在非转化乳腺上皮细胞系中在应激诱导的细胞凋亡中的作用。
6. WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells [O] . -1

机译：撤销：证据的蛋白酶体抑制剂的凋亡诱导活性在白血病细胞中NF-κBp65和特异性蛋白的关键作用
7. A Novel Role for a Familiar Protein in Apoptosis Induced by Proteasome Inhibition [O] . McConkey David J. 2008

机译：蛋白酶体抑制诱导的凋亡中的蛋白质的新型作用。

A novel role for a familiar protein in apoptosis induced by proteasome inhibition.

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