Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

Zeisig BB; Cheung N; Yeung J; So CW

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Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

机译：重建MLL-AF4白血病的疾病模型和表观遗传网络。

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The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.

机译：缺乏合适的动物模型阻碍了与MLL-AF4融合相关的白血病分子机制的理解。在本期《癌细胞》中，Krivtsov等人。报道了一个大大改善的小鼠Mll-AF4模型，并提出了一个由组蛋白甲基转移酶DOT1L介导的与H3K79甲基化的分子连接。

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《Cancer Cell》 |2008年第5期|共3页
作者
Zeisig BB; Cheung N; Yeung J; So CW;
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正文语种 eng
中图分类肿瘤学;
关键词
Animals; Disease Models; Animal; Epigenesis; Genetic; Gene Expression Regulation; Leukemic; 动物; 疾病模型; 动物; 基因表达调控; 白血病; 甲基化; 甲基转移酶类; 癌基因蛋白质类; 融合;

机译：Animals;Disease Models;Animal;Epigenesis;Genetic;Gene Expression Regulation;Leukemic;动物;疾病模型;动物;基因表达调控;白血病;甲基化;甲基转移酶类;癌基因蛋白质类;融合;

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1. Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia. [J] . Zeisig BB, Cheung N, Yeung J, Cancer Cell . 2008,第5期

机译：重建MLL-AF4白血病的疾病模型和表观遗传网络。
2. Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia. [J] . Hill VK, Dunwell TL, Catchpoole D, Epigenetics: official journal of the DNA Methylation Society . 2011,第3期

机译：萨尔瓦多/沃尔特/河马（SWH）肿瘤抑制网络上游成员KIBRA的频繁表观遗传失活与B细胞急性淋巴细胞白血病的特定遗传事件有关。
3. Reconstructing Genetic Regulatory Networks Using Two-Step Algorithms with the Differential Equation Models of Neural Networks [J] . Chi-Kan Chen Interdisciplinary Sciences: Computational Life Sciences . 2018,第4期

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4. Integration of Epigenetic Data in Bayesian Network Modeling of Gene Regulatory Network [C] . Jie Zheng, Iti Chaturvedi, Jagath C. Rajapakse Pattern recognition in bioinformatics . 2011

机译：基因调控网络的贝叶斯网络建模中表观遗传数据的整合
5. Stochastic modeling of epidemic diseases considering dynamic contact networks and genealogy information. [D] . Ashki, Haleh. 2015

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6. Reconstructing foot-and-mouth disease outbreaks: a methods comparison of transmission network models [O] . Simon M. Firestone, Yoko Hayama, Richard Bradhurst, -1

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7. Reconstructing the Disease Model and Epigenetic Networks for MLL-AF4 Leukemia [O] . Zeisig Bernd B., Cheung Ngai, Yeung Jenny, 2008

机译：重建MLL-AF4白血病的疾病模型和表观遗传网络

Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

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