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首页> 外文期刊>Cancer Cell >CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.
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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.

机译：CD4（+）T细胞通过增强巨噬细胞的肿瘤特性来调节乳腺癌的肺转移。

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摘要

During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent metastasis of mammary adenocarcinomas by directly regulating the phenotype and effector function of tumor-associated CD11b(+)Gr1(-)F4/80(+) macrophages that in turn enhance metastasis through activation of epidermal growth factor receptor signaling in malignant mammary epithelial cells. Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior.
机译：在乳腺癌的发展过程中，肿瘤性间质中白细胞的增加与疾病的发展平行。然而，白细胞在调节乳腺中的抗肿瘤和抗肿瘤免疫方面的功能意义仍然知之甚少。利用MMTV-PyMT模型的乳癌发生，我们证明IL-4表达CD4（+）T淋巴细胞通过直接调节肿瘤相关CD11b（+）Gr1的表型和效应子功能间接促进乳腺腺癌的侵袭和随后的转移。 （-）F4 / 80（+）巨噬细胞通过激活恶性乳腺上皮细胞中的表皮生长因子受体信号转而增强转移。总之，这些数据表明，抗肿瘤获得性免疫程序可以被篡改到肿瘤微环境中，而通过参与功能上参与调节上皮细胞行为的先天免疫系统的细胞成分来促进恶性肿瘤。

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