Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.

Jeselsohn R; Brown NE; Arendt

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Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.

机译：细胞周期蛋白D1激酶活性是MMTV-ErbB2肿瘤发生靶点的乳腺干细胞和祖细胞自我更新所必需的。

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Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self-renew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogenic transformation, correlating progenitor populations with certain oncogenic stimuli has been difficult. Cyclin D1 is required for lobuloalveolar development during pregnancy and lactation as well as MMTV-ErbB2- but not MMTV-Wnt1-mediated tumorigenesis. Using a kinase-deficient cyclin D1 mouse, we identified two functional mammary progenitor cell populations, one of which is the target of MMTV-ErbB2. Moreover, cyclin D1 activity is required for the self-renewal and differentiation of mammary progenitors because its abrogation leads to a failure to maintain the mammary epithelial regenerative potential and also results in defects in luminal lineage differentiation.

机译：移植研究表明，乳祖细胞具有自我更新和再生功能性乳腺的能力。尽管这些祖细胞可能是致癌转化的靶标，但很难将祖细胞与某些致癌刺激物联系起来。 Cyclin D1是孕期和哺乳期小叶肺泡发育以及MMTV-ErbB2-和MMTV-Wnt1介导的肿瘤发生所必需的。使用激酶缺陷细胞周期蛋白D1小鼠，我们确定了两个功能性乳祖细胞群体，其中之一是MMTV-ErbB2的目标。此外，细胞周期蛋白D1活性对于乳腺祖细胞的自我更新和分化是必需的，因为它的废除导致无法维持乳腺上皮的再生潜能，并且还导致管腔谱系分化的缺陷。

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《Cancer Cell》 |2010年第1期|共12页
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Jeselsohn R; Brown NE; Arendt;
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1. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. [J] . Jeselsohn R, Brown NE, Arendt Cancer Cell . 2010,第1期

机译：细胞周期蛋白D1激酶活性是MMTV-ErbB2肿瘤发生靶点的乳腺干细胞和祖细胞自我更新所必需的。
2. IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells [J] . Yixue Cao, Jun-li Luo, Michael Karin Proceedings of the National Academy of Sciences of the United States of America . 2007,第40期

机译：IκB激酶α激酶活性是ErbB2 / Her2转化乳腺肿瘤起始细胞自我更新所必需的
3. Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model. [J] . Jones JM, Cui XS, Medina D, Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research . 1999,第4期

机译：p21WAF1 / CIP1的杂合性增强了小鼠乳腺癌模型中的肿瘤细胞增殖和细胞周期蛋白D1相关的激酶活性。
4. Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Inducing Self-Renewal of Early Hematopoietic Progenitor Cells [C] . Jutta Friel, Christoph Heberlein, Maren Geldmacher, NATO Advanced Research Workshop on Stem Cells and their Potential for Clinical Application . 2008

机译：受体酪氨酸激酶亚类III膜结合同种型配体的作用在诱导早期造血祖细胞的诱导自我更新中
5. Over-expression of cell cycle kinases, cyclin D-Cdk4, cyclin E-Cdk2, and Aurora A kinase in estrogen-induced pre-neoplastic mammary lesions and tumors in the female ACI rat. [D] . Weroha, Saravut John. 2006

机译：细胞周期激酶，细胞周期蛋白D-Cdk4，细胞周期蛋白E-Cdk2和Aurora A激酶在雌激素诱发的雌性ACI大鼠的乳腺肿瘤前肿瘤病变和肿瘤中的过度表达。
6. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis [O] . Rinath Jeselsohn, Nelson E. Brown, Lisa Arendt, -1

机译：乳腺茎和祖细胞的自我更新是MMTV-ERBB2肿瘤瘤的靶标的自我更新所需的细胞周期蛋白D1激酶活性
7. Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis [O] . Jeselsohn Rinath, Brown Nelson E., Arendt Lisa, 2010

机译：细胞周期蛋白D1激酶活性对于作为MMTV-ErbB2肿瘤发生靶点的乳腺干细胞和祖细胞的自我更新是必需的

Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.

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