Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?

Ma Xenia G Ilagan; Raphael Kopan

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Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?

机译：通过SERCA抑制选择性阻断运输：切口形式的致癌性的答案？

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NOTCH1, which is frequently mutated in T?cell acute lymphoblastic leukemia, has been an elusive therapeutic target. In this issue of Cancer Cell, Roti and colleagues demonstrate that inhibiting SERCA calcium pumps preferentially impairs the maturation of the most common class of oncogenic Notch1 mutants, thus uncovering a potential therapeutic avenue.

机译：通常在T细胞急性淋巴细胞白血病中发生突变的NOTCH1已成为难以捉摸的治疗靶点。在本期《癌细胞》中，Roti及其同事证明了抑制SERCA钙泵会优先损害最常见的一类致癌Notch1突变体的成熟，从而揭示了一种潜在的治疗途径。

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《Cancer Cell》 |2013年第3期|共3页
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Ma Xenia G Ilagan; Raphael Kopan;
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正文语种 eng
中图分类肿瘤学;
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1. Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch? [J] . Ma Xenia G Ilagan, Raphael Kopan Cancer Cell . 2013,第3期

机译：通过SERCA抑制选择性阻断运输：切口形式的致癌性的答案？
2. Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia [J] . Marchesini Matteo, Gherli Andrea, Montanaro Anna, Protein and peptide letters . 2020,第6期

机译：用Serca抑制剂CAD204520在T细胞急性淋巴细胞白血病中阻断致癌术Notch1
3. Inhibition of Ca2+ transport in mitochondria by selective blockade of membrane mucopolysaccharides by hexamine cobaltichloride [J] . Gagelgans A.I., Makhmudova E.M., Mamatkulov Kh., FEBS Letters . 1972,第2期

机译：六胺四氯化钴选择性阻断膜粘多糖抑制线粒体中Ca2 +的运输
4. SUICIDE INHIBITION OF ONCOGENIC K-RAS G12C PROCEEDS VIA SHIFT TO THE INACTIVE CONFORMATION [C] . Rane A. Harrison, Sang Min Lim, John C. Hunter, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：致癌k-ras g12c的自杀抑制通过转移到非活动构象进行
5. Informing Therapeutic Approaches for Infectious Disease and Heart Disease, Focusing on Cell-Free Synthesis of Bacteriophages and Calcium Transport by SERCA [D] . Rustad, Mark David. 2020

机译：通知传染病和心脏病的治疗方法，专注于SERCA无细胞合成噬菌体和钙转运
6. Isoform-selective Inhibition of Facilitative Glucose Transporters [O] . Richard C. Hresko, Thomas E. Kraft, Anatoly Tzekov, 2014

机译：促进葡萄糖转运蛋白的同工型选择性抑制
7. Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch? [O] . Ilagan Ma. Xenia G., Kopan Raphael 2013

机译：通过SERCA抑制选择性阻滞运输：切口的致癌形式的答案？
8. Oncogenicity and Selective Inhibition of ERG Splicing Variants in Prostate Cancer. [R] . Cartegni, L., Boutsalis, G., Rocco, G., 2012

机译：ERG剪接变异体在前列腺癌中的致癌性和选择性抑制作用。

Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?

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