The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein- coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.
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机译：长非编码RNA（lncRNA）的发现极大地改变了我们对癌症的理解。在这里，我们描述了来自The Cancer Genome Atlas的13种癌症类型中的5,037个人类肿瘤标本在转录，基因组和表观遗传水平上的lncRNA改变的全面分析。我们的结果表明，与蛋白质编码基因相比，lncRNA的表达和失调具有高度的癌症类型特异性。使用此分析生成的综合数据，我们提出了临床指导的小干扰RNA筛选策略和共表达分析方法，以识别癌症驱动程序lncRNAs并预测其功能。这为研究lncRNA在癌症中的研究提供了资源，并为开发新的诊断方法和治疗方法奠定了基础。
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