Splicing and Dicing MYC-Mediated Synthetic Lethality

Stine Zachary E.; Dang Chi V.

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Splicing and Dicing MYC-Mediated Synthetic Lethality

机译：拼接和切丁MYC介导的合成致命性

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In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

机译：Hsu及其同事在最近一期的《自然》杂志上报告说，致癌的MYC激活具有合成致命性，并抑制了核心剪接体，因为MYC驱动的生长和转录增加使肿瘤依赖于前mRNA加工来生存。由于直接靶向MYC仍然难以捉摸，因此合成致死策略颇具吸引力。

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《Cancer Cell》 |2015年第4期|共2页
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Stine Zachary E.; Dang Chi V.;
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正文语种 eng
中图分类肿瘤学;
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专利

1. Splicing and Dicing MYC-Mediated Synthetic Lethality [J] . Stine Zachary E., Dang Chi V. Cancer Cell . 2015,第4期

机译：拼接和切丁MYC介导的合成致命性
2. MYC-Mediated Synthetic Lethality for Treating Tumors [J] . Li Xin, Zhang Xin A., Li Xiaoqing, Current cancer drug targets . 2015,第2期

机译：MYC介导的合成致死性治疗肿瘤
3. MYC-mediated Synthetic Lethality for Treatment of Hematological Malignancies [J] . Li Xin, Zhang Xin A., Xie Wei, Current cancer drug targets . 2015,第1期

机译：MYC介导的合成致死性治疗血液系统恶性肿瘤
4. Syn-Lethality: An integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies [C] . Xue-juan Li, Mishra S.K., Min Wu, IEEE International Conference on Bioinformatics and Biomedicine . 2013

机译：合成致死性：合成致死性的综合知识库，用于发现选择性抗癌疗法
5. Lethal and sub-lethal effects of selected synthetic insecticides on two cotton thrips pests: Onion thrips, Thrips tabaci, and western flower thrips, Frankliniella occidentalis [D] . Janis, Jonathan A. 2008

机译：选定的合成杀虫剂对两种棉蓟马害虫的致死和亚致死作用：洋葱蓟马，烟蓟马和西方花蓟马，西方富兰克氏菌
6. Synthetic Lethality of Yeast slt Mutations with U2 Small Nuclear RNA Mutations Suggests Functional Interactions between U2 and U5 snRNPs That Are Important for Both Steps of Pre-mRNA Splicing [O] . Deming Xu, Deborah J. Field, Shou-Jiang Tang, 1998

机译：酵母菌slt突变与U2小核RNA突变的合成致死性表明U2和U5 snRNP之间的功能相互作用对于前mRNA剪接的两个步骤都很重要
7. Splicing and Dicing MYC-Mediated Synthetic Lethality [O] . Stine Zachary E., Dang Chi V. 2015

机译：拼接和切丁MYC介导的合成致命性

Splicing and Dicing MYC-Mediated Synthetic Lethality

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