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首页> 外文期刊>Cancer Cell >The challenges of gene expression microarrays for the study of human cancer.
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The challenges of gene expression microarrays for the study of human cancer.

机译：基因表达微阵列对人类癌症研究的挑战。

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摘要

Large-scale genomic studies promise to advance our understanding of the biology of human cancers and to improve their diagnosis, prognostication, and treatment. The analysis and interpretation of genomics studies have faced challenges. The retrospective and observational design of many studies has rendered them susceptible to confounding and bias. Technological variations and advances have impacted on reproducibility. Statistical hurdles in relating a large number of variables to a small number of observations have added further constraints. This review considers the promise and challenge associated with the large-scale clinically oriented genomic analysis of human cancer and attempts to emphasize potential solutions.
机译：大规模的基因组研究有望增进我们对人类癌症生物学的理解，并改善其诊断，预后和治疗。基因组学研究的分析和解释面临挑战。许多研究的回顾性和观察性设计使他们容易产生混淆和偏见。技术的变化和进步已经影响了可重复性。将大量变量与少量观测值相关联的统计障碍增加了进一步的限制。这篇评论考虑了与人类癌症的大规模临床定向基因组分析相关的希望和挑战，并试图强调潜在的解决方案。

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