...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Cell >Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.
【24h】

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.

机译：急性髓样白血病在具有CALM / AF10阳性白血病的小鼠模型中通过具有淋巴样特征的白血病干细胞繁殖。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. Furthermore, depletion of B220+ cells in leukemic transplants impaired development of leukemia in recipients. As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells. These data demonstrate in a murine leukemia model that AML can be propagated by a transformed progenitor with lymphoid characteristics, which can be targeted by antibodies that do not crossreact with normal HSCs.
机译：在急性髓性白血病（AML）中选择性靶向白血病干细胞的疗法的发展面临的挑战是它们与正常造血干细胞（HSC）的相似性。在这里，我们证明了鼠CALM / AF10阳性AML中的白血病传播细胞与正常HSC的区别在于B220表面表达和免疫球蛋白重链重排。此外，白血病移植物中B220 +细胞的耗竭会削弱受体中白血病的发生。与鼠模型一样，人CALM / AF10阳性AML的特征是CD45RA（B220）阳性，IG DH-JH重排的白血病细胞。这些数据在鼠类白血病模型中证明了AML可以通过具有淋巴样特征的转化祖细胞进行繁殖，而该祖细胞可以被不与正常HSC交叉反应的抗体靶向。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号